Active Recombinant Human DMPK, GST-tagged
Cat.No. : | CDC42BPG-1396H |
Product Overview : | Recombinant full-length human DMPK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
Protein Length : | Full length |
Description : | DMPK (or Myotonic Dystrophy Protein Kinase) is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. DMPK protein has a leucine-rich domain at the N-terminus, a serine/threonine kinase domain in the middle, and a hydrophobic region at the C-terminus. The N-terminus of DMPK plays an important role in DMPK kinase activity, and the C-terminus of DMPK determines the intracellular localization of the protein. Myotonic dystrophy type 1 is an autosomal dominant disease caused by a trinucleotide repeat-expansion, cytosine-thymine-guanine (CTG)n, in the 3 untranslated region of DMPK. |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 4.5 nmol/min/mg |
Molecular Mass : | ~105kDa |
Purity : | >90% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name | CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) [ Homo sapiens ] |
Official Symbol | CDC42BPG |
Synonyms | CDC42BPG; CDC42 binding protein kinase gamma (DMPK-like); serine/threonine-protein kinase MRCK gamma; DMPK2; HSMDPKIN; kappa 200; MRCKgamma; MRCK gamma; DMPK-like gamma; CDC42-binding protein kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; myotonic dystrophy protein kinase like protein; myotonic dystrophy kinase-related CDC42-binding kinase gamma; MRCKG; KAPPA-200; |
Gene ID | 55561 |
mRNA Refseq | NM_017525 |
Protein Refseq | NP_059995 |
MIM | 613991 |
UniProt ID | Q6DT37 |
Chromosome Location | 11q13 |
Function | ATP binding; ATP binding; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; small GTPase regulator activity; |
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Not For Human Consumption!
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