Active Recombinant Human DKK1, MIgG2a Fc-tagged
| Cat.No. : | DKK1-385H |
| Product Overview : | The extracellular domain of human DKK-1 (AAH01539.1)(Thr32-His266) is fused to the N-terminus of the Fc region of mouse lgG2a was expressed in CHO cell. |
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| Description : | This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteinerich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway.Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolyticbone lesions in patients with multiple myeloma. |
| Source : | CHO cell |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production. |
| Molecular Mass : | 52KDa (monomer) |
| AA Sequence : | Thr32-His266 |
| Endotoxin : | <0.06 eu/μg="" as="" determined="" by="" lal="" test.=""> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Protein length : | 32-266 a.a. |
| Gene Name | DKK1 dickkopf 1 homolog (Xenopus laevis) [ Homo sapiens ] |
| Official Symbol | DKK1 |
| Synonyms | DKK1; dickkopf 1 homolog (Xenopus laevis); dickkopf (Xenopus laevis) homolog 1; dickkopf-related protein 1; DKK 1; SK; hDkk-1; dickkopf-1 like; dickkopf related protein-1; DKK-1; |
| Gene ID | 22943 |
| mRNA Refseq | NM_012242 |
| Protein Refseq | NP_036374 |
| MIM | 605189 |
| UniProt ID | O94907 |
| Chromosome Location | 10q11.2 |
| Pathway | Direct p53 effectors, organism-specific biosystem; Presenilin action in Notch and Wnt signaling, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Validated targets of C-MYC transcriptional repression, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt signaling network, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; |
| Function | growth factor activity; low-density lipoprotein particle receptor binding; protein binding; receptor antagonist activity; signal transducer activity; |
Not For Human Consumption!
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