Active Recombinant Human DcR3, HIgG1 Fc-tagged

• Cat.No.: DcR3-678H
• Product Overview: A soluble dimeric fusion protein consisting of the extracellular domain of human DcR3(O95407) (Val24-His300) was fused to human IgG1 Fc.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 24-300 a.a.
• Description: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• AA Sequence: A soluble dimeric fusion protein consisting of the extracellular domain of human DcR3(O95407) (Val24-His300) was fused to human IgG1 Fc.
• Endotoxin: <0.06eu mu;g="" as="" determined="" by="" lal="">
• Purity: >98%(SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy [ Homo sapiens (human) ]
• Official Symbol: DcR3
• Synonyms: TNFRSF6B; M68; TR6; DCR3; M68E; DJ583P15.1.1; tumor necrosis factor receptor superfamily, member 6b, decoy; tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand
• Gene ID: 8771
• mRNA Refseq: NM_003823
• Protein Refseq: NP_003814
• MIM: 603361
• UniProt ID: O95407
• Chromosome Location: 20q13.3
• Pathway: Apoptosis Modulation and Signaling; Cytokine-cytokine receptor interaction; Cytosolic Iron-sulfur Cluster Assembly
• Function: protein binding; receptor activity