Active Recombinant Human CD80, MIgG2a Fc-tagged
| Cat.No. : | CD80-616H |
| Product Overview : | The extracellular domain of human CD80 [B7-1] (NP_005182.1) (Val35-Asn242) is fused to the N-terminus of the Fc region of mouseIgG2a. |
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| Description : | The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. |
| Source : | CHO cells |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured by its ability to induce IL-2 secretion by Jurkat human acute T cell leukemia cells. |
| Molecular Mass : | 50 KDa (monomer) |
| AA Sequence : | Val35-Asn242 |
| Endotoxin : | <0.06 eu/μg="" as="" determined="" by="" lal="" test.=""> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Protein length : | 35-242 a.a. |
| Gene Name | CD80 CD80 molecule [ Homo sapiens ] |
| Official Symbol | CD80 |
| Synonyms | CD80; CD80 molecule; CD28LG, CD28LG1, CD80 antigen (CD28 antigen ligand 1, B7 1 antigen) , CD80 molecule; T-lymphocyte activation antigen CD80; B lymphocyte activation antigen B7; B7 1; B7.1; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); B7; BB1; B7-1; LAB7; CD28LG; CD28LG1; |
| Gene ID | 941 |
| mRNA Refseq | NM_005191 |
| Protein Refseq | NP_005182 |
| MIM | 112203 |
| UniProt ID | P33681 |
| Chromosome Location | 3q13.3-q21 |
| Pathway | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; |
| Function | coreceptor activity; protein binding; receptor activity; |
Not For Human Consumption!
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