Active Recombinant Human CD109, His-tagged

• Cat.No.: CD109-108H
• Product Overview: Recombinant Human CD109, Val22-Ser1268 (Tyr703Ser & Thr1241Met), fused with a C-terminal 10-His tag, was expressed in Mouse NSO Cells.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 22-1268 a.a.
• Description: This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.
• Predicted N Terminal: Val22
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to bind TGF-beta 1 in a functional ELISA. Immobilized rhTGF-beta 1 at 1 µg/mL (100 µL/well) can bind rhCD109 with an apparent KD < 0.1 µM.
• Molecular Mass: Predicted Molecular Mass: 141 kDaSDS-PAGE: 155-165 kDa, reducing conditions
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 100 µg/mL in sterile PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: CD109 CD109 molecule [ Homo sapiens (human) ]
• Official Symbol: CD109
• Synonyms: CD109; CD109 molecule; p180; r150; CPAMD7; CD109 antigen; Gov platelet alloantigens; activated T-cell marker CD109; platelet-specific Gov antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
• Gene ID: 135228
• mRNA Refseq: NM_133493
• Protein Refseq: NP_598000
• MIM: 608859
• UniProt ID: Q6YHK3
• Chromosome Location: 6q13
• Function: serine-type endopeptidase inhibitor activity; transforming growth factor beta binding