Active Recombinant Human CCL11

• Cat.No.: CCL11-172H
• Product Overview: Human CCL11 (P51671, 1 a.a.-97 a.a.) full-length recombinant protein. expressed in Escherichia coli.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
• Sequence: MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR RITSGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP
• Theoretical MW (kDa): 9
• Form: Liquid
• Preparation Method: E. coli expression system
• Purity: > 97% by SDS-PAGE and HPLC
• Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
• Activity: Activity was determined by the ability to induce chemotaxis of purified eosinophils at concentrations ranging between 50-100 ng/mL.
• Application: Functional Study; SDS-PAGE
• Storage Buffer: In 100 mM NaCl, 20 mM Tris (0.1 M glycerol) pH 8.0
• Storage: Store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P51671
• Pathways: Asthma; Chemokine signaling pathway; Cytokine-cytokine receptor interaction

Gene Information

• Gene Name: CCL11 chemokine (C-C motif) ligand 11 [ Homo sapiens ]
• Official Symbol: CCL11
• Synonyms: CCL11; chemokine (C-C motif) ligand 11; C-C motif chemokine 11; eotaxin; eotaxin-1; Eosinophil chemotactic protein; MGC22554; Small-inducible cytokine A11; small inducible cytokine A11; SCYA11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
• Gene ID: 6356
• mRNA Refseq: NM_002986
• Protein Refseq: NP_002977
• MIM: 601156
• Chromosome Location: 17q21.1-q21.2
• Function: chemokine activity