Active Recombinant Human BRD2 Protein (339-459), N-His tagged

• Cat.No.: BRD2-34H
• Product Overview: Active Recombinant human BRD2 (339-459) was expressed in E. coli cells using an N-terminal His tag.

Specification

• Description: Bromodomain-containing protein 2 (BRD2) is a member of the bromodomain and extra-terminal domain (BET) protein family. BRD2 is known to interact with transcriptional machinery and chromatin remodeling complexes, enabling its involvement in the regulation of gene expression. By binding to acetylated histones, BRD2 recruits transcriptional activators or repressors, thereby modulating the accessibility of DNA to transcription factors and RNA polymerase machinery. BRD2 has been found to contribute to the development of cancer by regulating the expression of oncogenes or tumor suppressor genes.
• Source: E. coli
• Species: Human
• Tag: His
• Bio-activity: 1,272 ng/min/mg
• Molecular Mass: Observed MW: ~15 kDa
  Calculated MW: ~14.6 kDa
• Protein length: 339-459
• Purity: > 90%
• Stability: One year at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: BRD2 bromodomain containing 2 [ Homo sapiens (human) ]
• Official Symbol: BRD2
• Synonyms: BRD2; bromodomain containing 2; bromodomain-containing protein 2; D6S113E; FSRG1; KIAA9001; NAT; RING3; O27.1.1; bromodomain-containing 2; really interesting new gene 3 protein; female sterile homeotic-related gene 1; FSH; RNF3; FLJ31942; DKFZp686N0336
• Gene ID: 6046
• mRNA Refseq: NM_005104
• Protein Refseq: NP_005095
• MIM: 601540
• UniProt ID: P25440