Active Recombinant Human BIRC2 protein, His-tagged

• Cat.No.: BIRC2-01H
• Product Overview: Recombinant Human BIRC2 protein, fused to His-tag, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: cIAP-1 (also known as MIHB and HIAP-2) is a member of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. cIAP-1 has 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). cIAP-1 inhibits caspases by interaction of the BIR domain with the active caspase. Caspase activity may be restored through interactions with the Reaper like motif on mitochondrial proteins such as SMAC/Diablo or HTRA-2/Omi. cIAP-1 is reported to be cleaved by caspases in fetal rat hepatocytes treated with TGF-beta.
• Form: Supplied as a 0.2 μm filtered solution in HEPES, NaCl, DTT and Glycerol.
• Bio-activity: Measured by its ability to inhibit DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP. The IC50 for this effect is 25-1000 nM.
• Molecular Mass: Predicted Molecular Mass:72 kDa
  SDS-PAGE: 68 kDa, reducing conditions
• N-terminal Sequence Analysis: Ala
• Purity: >85%
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -70 centigrade as supplied.
  3 months, -70 centigrade under sterile conditions after opening.
• Shipping: The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: BIRC2 baculoviral IAP repeat containing 2 [ Homo sapiens (human) ]
• Official Symbol: BIRC2
• Synonyms: API1Hiap-2; apoptosis inhibitor 1; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing protein 2; BIRC2; cIAP1; c-IAP1; cIAP-1; hIAP2; HIAP-2; IAP homolog B; IAP2; IAP-2; Inhibitor of apoptosis protein 2; MIHB; MIHBHIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RNF48hiap-2; TNFR2-TRAF-signaling complex protein 2
• Gene ID: 329
• mRNA Refseq: NM_001166.5
• Protein Refseq: NP_001157.1
• MIM: 601712
• UniProt ID: Q13490