Active Recombinant Human BDNF Protein

• Cat.No.: BDNF-007H
• Product Overview: The mature recombinant human BDNF protein consists of 119 amino acids (129-247) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 129-247 a.a.
• Description: This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.
• Bio-activity: ED50 = 1 - 3 μg/mL as measured by the ability of the protein to induce the proliferation of C6 glioma cells.
• Molecular Mass: 27 kDa
• Product-Related Proteins: 129-247
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: BDNF brain derived neurotrophic factor [ Homo sapiens (human) ]
• Official Symbol: BDNF
• Synonyms: BDNF; brain derived neurotrophic factor; ANON2; BULN2; brain-derived neurotrophic factor; Names; abrineurin; neurotrophin
• Gene ID: 627
• mRNA Refseq: NM_170735
• Protein Refseq: NP_733931
• MIM: 113505
• UniProt ID: P23560