Active Recombinant Human ATM Protein (Full Length), Flag-tagged

Cat.No. : ATM-186H
Product Overview : Recombinant active human FLAG-tagged ATM full length protein was expressed in a mammalian cell line.
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Species : Human
Source : Mammalian Cells
Tag : Flag
Description : The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Form : Protein in frozen storage buffer.
Molecular Mass : 352 kDa
Storage : 6 months at -70 centigrade.
Full Length : Full L.
Gene Name ATM ATM serine/threonine kinase [ Homo sapiens (human) ]
Official Symbol ATM
Synonyms ATM; ATM serine/threonine kinase; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated; serine/threonine kinase ATM; EC 2.7.11.1
Gene ID 472
mRNA Refseq NM_000051
Protein Refseq NP_000042
MIM 607585
UniProt ID Q13315

Not For Human Consumption!

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