Active Recombinant Human ATM Protein (Full Length), Flag-tagged
Cat.No. : | ATM-186H |
Product Overview : | Recombinant active human FLAG-tagged ATM full length protein was expressed in a mammalian cell line. |
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Species : | Human |
Source : | Mammalian Cells |
Tag : | Flag |
Description : | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. |
Form : | Protein in frozen storage buffer. |
Molecular Mass : | 352 kDa |
Storage : | 6 months at -70 centigrade. |
Full Length : | Full L. |
Gene Name | ATM ATM serine/threonine kinase [ Homo sapiens (human) ] |
Official Symbol | ATM |
Synonyms | ATM; ATM serine/threonine kinase; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated; serine/threonine kinase ATM; EC 2.7.11.1 |
Gene ID | 472 |
mRNA Refseq | NM_000051 |
Protein Refseq | NP_000042 |
MIM | 607585 |
UniProt ID | Q13315 |
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Not For Human Consumption!
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