Active Recombinant Full Length Human PTPN6 protein, His-tagged

• Cat.No.: PTPN6-289H
• Product Overview: Recombinant Human PTPN6 fused with His tag at C-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-595 a.a.
• Description: PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.
• Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Bio-activity: 2500 nmol/min/mg
• Molecular Mass: 67 kDa
• Purity: > 95%
• Applications: Phosphatase Assay, Western Blot
• Stability: 1 year at -70 centigrade from the date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PTPN6 protein tyrosine phosphatase, non-receptor type 6 [ Homo sapiens ]
• Official Symbol: PTPN6
• Synonyms: PTPN6; protein tyrosine phosphatase, non-receptor type 6; tyrosine-protein phosphatase non-receptor type 6; HCP; HCPH; PTP 1C; SHP 1; SHP1; hematopoietic cell phosphatase; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; hematopoietic cell protein-tyrosine phosphatase; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
• Gene ID: 5777
• mRNA Refseq: NM_080548
• Protein Refseq: NP_536858
• MIM: 176883
• UniProt ID: P29350
• Chromosome Location: 12p13.31
• Pathway: Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem
• Function: hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity