PTPN6
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Official Full Name
protein tyrosine phosphatase, non-receptor type 6 -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
PTPN6;protein tyrosine phosphatase, non-receptor type 6;HCP;HCPH;SHP1;SHP-1;HPTP1C;PTP-1C;SHP-1L;SH-PTP1;tyrosine-protein phosphatase non-receptor type 6;hematopoietic cell phosphatase;protein-tyrosine phosphatase 1C;protein-tyrosine phosphatase SHP-1;hematopoietic cell protein-tyrosine phosphatase
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- His
- Non
- GST
- His&GST
- His&Strep
- Myc&DDK
- Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
PTPN6 involved in several pathways and played different roles in them. We selected most pathways PTPN6 participated on our site, such as Adherens junction,Jak-STAT signaling pathway,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | RAET1G,IFNA2,MAP2K1,KIR2DL3,IFNAR2,PIK3CG,HCST,H60a,RAC1,IFNG |
| Leishmaniasis | STAT1,IL12A,NOS2,C3,IRAK1,RELA,FCGR1,HLA-DRB3,MAPK13,MAPK11 |
| Proteoglycans in cancer | MAPK13,ITGB3,ROCK1,CDC42,RPS6KB1,SDC1,PPP1CA,TWIST1,FZD3,CD44 |
| Jak-STAT signaling pathway | CSH1,FHL1B,STAT2,PTPN11B,MCL1A,SOCS2,IL5RA,GHRA,IL22RA2,PIAS2 |
| B Cell Receptor Signaling Pathway | CD79B,CD79A,PPP3CB,BLNK,IKBKG,FCGR2B,PPP3CA,VAV3,PPP3R1,CDK6 |
| T cell receptor signaling pathway | MAP2K7,CBLB,SOS1,PTPRC,HRAS,CARD11,AKT2,PAK1,MAPK3,CD3E; CD3D |
| Adherens junction | RHOAC,PVRL1B,CTNNA1,SMAD3,PTPN1,ACTG1,CSNK2A2A,WASB,ACTN1,ACTN3 |
Protein Function
PTPN6 has several biochemical functions, for example, protein binding,protein kinase binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN6 itself. We selected most functions PTPN6 had, and list some proteins which have the same functions with PTPN6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | DUSP3,PTP4A2B,MTMR1,MTM1,PTPRM,DUSP13,PALD1B,MTMR1A,MTMR1B,UBASH3B |
| transmembrane receptor protein tyrosine phosphatase activity | PTPRG,PTPRA,PTPRR,PTPRC,PTPRD,PTPRF,PTPRUB,PTPRB,EVLA,PTPRO |
| protein kinase binding | STXBP1,POLA1,KCNH1,JAK2,PAX6,TELO2,BCL2L14,PKD1,AKAP1,CD4 |
| protein binding | IPO11,ERP44,KIAA0408,HEBP2,NTM,GEM,PBRM1,KAT2B,CYFIP2,STRADA |
Interacting Protein
PTPN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN6.
KIR2DL3;EPOR
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References
- Li, YF; Xu, SL; et al. Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool. NATURE COMMUNICATIONS 5:-(2014).
- Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).
