Active Recombinant Cynomolgus IL23R protein, Fc-tagged

• Cat.No.: IL23R-0271C
• Product Overview: Recombinant Cynomolgus IL23R protein(Gly24-Asp353), fused with Fc tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Cynomolgus
• Tag: Fc
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
• Bio-activity: Immobilized Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate can bind Cynomolgus IL-23 R, Fc Tag with a linear range of 0.1-3 ng/mL.
• Molecular Mass: This protein carries a human IgG1 Fc tag at the C-terminusThe protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Proteinlength: Gly24-Asp353
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
  -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Protein length: Gly24-Asp353
• Official Symbol: IL23R

Gene Information

• Official Symbol: IL23R

Reviews

10/21/2020

High specificity in ELISA.

04/28/2016

Effective in autoimmune models.

03/30/2016

Suitable for receptor binding studies.

Q&As

How does IL23R activation affect T-cell differentiation?

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants?

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability?

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells?

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression?

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release?

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases?

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection?

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers?

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R?

IL23R activates the JAK-STAT and NF-κB pathways.