Active Recombinant Bovine Interleukin 4

Cat.No. : IL4-240B
Product Overview : Recombinant Bovine IL-4 was expressed inYeast. MW= 12.6 kDa (112 aa).
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Species : Bovine
Source : Yeast
Tag : Non
Description : Interleukin-4, abbreviated IL-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. Its receptor is the Interleukin-4 receptor.
Formulation/ Reconstitution : Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Purification : Ion-exchange chromatography.
Purity : >95% as visualized by SDS-PAGE analysis.
Amino Acid Sequence : GHKCDITLAE IIKTLNILTT RKNSCMELPV ADVFAAPKNT TEKETFCRVG IELRRIYRSH TCLNKFLGGL DRNLNSLASK TCSVNEAKTS TSTLKDLLER LKTIMKEKYS KC.
Bioactivity : The biological activity of recombinant bovine IL-4 was measured in a cell proliferation assay using the human TF-1 cell line. The ED50 for this effect is typically 1.5 - 2 ng/mL.
Stability And Storage : Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Gene Name IL4 interleukin 4 [ Bos taurus ]
Synonyms interleukin 4; IL4; IL-4; interleukin-4; BSF-1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1
Gene ID 280824
mRNA Refseq NM_173921.2
Protein Refseq NP_776346.1
UniProt ID P30367
Chromosome Location 7q15-q21
Pathway Allograft rejection; Asthma; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Hematopoietic cell lineage; Intestinal immune network for IgA production; Jak-STAT signaling pathway; T cell receptor signaling pathway
Function cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding

Not For Human Consumption!

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