Active Recombinant Bovine Interleukin 4
Cat.No. : | IL4-240B |
Product Overview : | Recombinant Bovine IL-4 was expressed inYeast. MW= 12.6 kDa (112 aa). |
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Species : | Bovine |
Source : | Yeast |
Tag : | Non |
Description : | Interleukin-4, abbreviated IL-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. Its receptor is the Interleukin-4 receptor. |
Formulation/ Reconstitution : | Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
Purification : | Ion-exchange chromatography. |
Purity : | >95% as visualized by SDS-PAGE analysis. |
Amino Acid Sequence : | GHKCDITLAE IIKTLNILTT RKNSCMELPV ADVFAAPKNT TEKETFCRVG IELRRIYRSH TCLNKFLGGL DRNLNSLASK TCSVNEAKTS TSTLKDLLER LKTIMKEKYS KC. |
Bioactivity : | The biological activity of recombinant bovine IL-4 was measured in a cell proliferation assay using the human TF-1 cell line. The ED50 for this effect is typically 1.5 - 2 ng/mL. |
Stability And Storage : | Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles. |
Gene Name | IL4 interleukin 4 [ Bos taurus ] |
Synonyms | interleukin 4; IL4; IL-4; interleukin-4; BSF-1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1 |
Gene ID | 280824 |
mRNA Refseq | NM_173921.2 |
Protein Refseq | NP_776346.1 |
UniProt ID | P30367 |
Chromosome Location | 7q15-q21 |
Pathway | Allograft rejection; Asthma; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Hematopoietic cell lineage; Intestinal immune network for IgA production; Jak-STAT signaling pathway; T cell receptor signaling pathway |
Function | cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding |
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Not For Human Consumption!
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