Active Native Human PF 4

• Cat.No.: PLF4-88H

Specification

• Species: Human
• Source: Human Platelets
• Tag: Non
• Description: Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues
• Form: Lyophilized protein
• Bio-activity: Binding of HIT-antibodies
• Molecular Mass: 7.8 kDa
• AA Sequence: The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu
• Purity: Purity by SDS-PAGE: ≥95%; Purity by HPLC: ≥95%
• Usage: For Research Use Only! Not For Use in Humans.
• Notes: Centrifuge the vial prior to opening
• Storage: -20°C
• Storage Buffer: Lyophilized from PBS buffer, pH 7.4
• Reconstitution: Reconstitute in sterile ddH?O to a concentration ≥ 100 μg/ml. This solution can then be diluted into other aqueous buffers
• Shipping: Gel pack

Gene Information

• Gene Name: PF4 platelet factor 4 [ Homo sapiens ]
• Official Symbol: PLF4
• Synonyms: PF-4; CXCL4; SCYB4; platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4
• Gene ID: 5196
• mRNA Refseq: NM_002619
• Protein Refseq: NP_002610
• MIM: 173460
• UniProt ID: P02776
• Chromosome Location: 4q12-q21
• Pathway: CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Common Pathway, organism-specific biosystem
• Function: CXCR3 chemokine receptor binding; chemokine activity