Active Native Human MMP8 Protein

• Cat.No.: MMP8-1656H
• Product Overview: Native human MMP8 protein was isolated from stimulated human neutrophil granulocytes (buffy coat)

Specification

• Species: Human
• Source: Neutrophil granulocytes
• Description: This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
• Form: Liquid
• Bio-activity: ≥60 mU/mg protein. One unit is defined as the amount of enzyme that hydrolyzes 1 μmol 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH per min. at 37 centigrade, pH 7.0.
• Molecular Mass: ~85 kDa
• Purity: ≥90% by SDS-PAGE
• Stability: Stable for 1 week when stored at +4 centigrade and for serveral weeks when stored at -20 centigrade.
• Storage: At -80 centigrade
• Concentration: 100 μg/ml
• Storage Buffer: In 50mM TRIS-HCl, pH 7.0, containing 200mM NaCl, 5mM CaCl2, 1μM ZnCl2, 0.05% BRIJ 35, and 0.05% sodium azide.
• Handling: Avoid freeze/thaw cycles.
• Shipping: Shipped on Dry Ice

Gene Information

• Gene Name: MMP8 matrix metallopeptidase 8 [ Homo sapiens (human) ]
• Official Symbol: MMP8
• Synonyms: MMP8; matrix metallopeptidase 8; 3.4.24.34; HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMN leukocyte collagenase; PMNL collagenase; collagenase 2; matrix metalloproteinase 8 (neutrophil collagenase); matrix metalloproteinase-8; EC 3.4.24.34
• Gene ID: 4317
• mRNA Refseq: NM_002424
• Protein Refseq: NP_002415
• MIM: 120355
• UniProt ID: P22894