Active Native Human Kallikrein

• Cat.No.: KLKB1-210H
• Product Overview: Purified Native Human Urine Kallikrein. CAS Number: 9001-01-8; E.C. Number: 3.4.21.35

Specification

• Species: Human
• Source: Human Urine
• Tag: Non
• Description: Human Kallikrein protein, also known as Urokallikrein, is an enzyme present in blood plasma, lymph, urine, saliva, pancreatic juices, and other body fluids that catalyzes the proteolysis of bradykininogen to bradykinin. Also called kininogenase.Kallikrein is the target of an active investigation by drug researchers as possible bio-marker for cancer.
• Form: Liquid in proprietary buffer
• Bio-activity: >10 pNA units/mL
• Molecular Mass: 44000
• Purity: >99% (SDS-PAGE)
• Unit Definition: One unit will hydrolize 1.0 umole of H-D-Val-Leu-Arg-pNA(S-2266) per minute at pH 8.0 at 37C
• Storage: Store at 2-8 °C.

Gene Information

• Gene Name: KLKB1 kallikrein B, plasma (Fletcher factor) 1 [ Homo sapiens ]
• Official Symbol: KLKB1
• Synonyms: KLKB1; kallikrein B, plasma (Fletcher factor) 1; KLK3; plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain; PPK
• Gene ID: 3818
• mRNA Refseq: NM_000892
• Protein Refseq: NP_000883
• MIM: 229000
• UniProt ID: P03952
• Chromosome Location: 4q35
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem
• Function: peptidase activity; protein binding; serine-type endopeptidase activity