Active Native Human CAPN1

• Cat.No.: CAPN1-8448H

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: Ca2+-dependent cysteine proteinase with low Ca2+ requirement (half maximal activation = 2 μM). Participates in the ATP release reaction of platelets stimulated with thrombin. Involves in apoptosis activation.
• Form: In 20 mM imidazole-HCl, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
• Bio-activity: >1000 units/mg protein
• Molecular Mass: 112.0 kDa
• Purity: ≥95% by SDS - PAGE
• Storage: Store at –70°C, stable for at least 1 year as supplied. Avoid freeze/thaw cycles.
• Shipping: gel pack

Gene Information

• Gene Name: CAPN1 calpain 1, (mu/I) large subunit [ Homo sapiens ]
• Official Symbol: CAPN1
• Synonyms: CAPN1; calpain 1, (mu/I) large subunit; calpain-1 catalytic subunit; CANP; CANPL1; muCANP; muCL; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein; CANP1
• Gene ID: 823
• mRNA Refseq: NM_001198868
• Protein Refseq: NP_001185797
• MIM: 114220
• UniProt ID: P07384
• Chromosome Location: 11q13
• Pathway: Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Focal Adhesion, organism-specific biosystem; Integrin-mediated cell adhesion, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem
• Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; peptidase activity; protein binding