Active GMP Recombinant Human FGF4 Protein

• Cat.No.: FGF4-01HG
• Product Overview: Recombinant human FGF4 protein, was expressed in CHO-K1 cell-derived in an animal component free process under cGMP guidelines.

Specification

• Species: Human
• Source: CHO
• Description: Fibroblast growth factor-4 (FGF-4), also known as FGF-K or K-FGF, a heparin-binding growth factor, is a member of the FGF family. Proteins of this family play a central role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and differentiation. Mature human FGF4 shares 91%, 82%, 94%, and 91% AA properties with mouse, rat, canine, and bovine FGF4, and human FGF-4 exhibits cross-species activity. The expression of FGF-4 and its receptors, i.e. FGF R1c, 2c, 3c, and 4, is spatiotemporally regulated during embryonic development. fGF-4 has a physiologically relevant role in human embryonic stem cell self-renewal. fGF-4 not only promotes the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induces BMSCs to form hepatocyte-like cells in vitro. fGF4-induced bone marrow MSCs can promote liver regeneration through the microenvironment of transplantation. Thus, FGF4- bFGF-BMSCs can improve the survival of transplanted cells, reduce myocardial fibrosis, promote myocardial angiogenesis, and improve cardiac function. fGF-4 promotes fibroblast and endothelial cell mitosis in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been used to treat coronary artery disease.
• Form: Lyophilized powder
• Endotoxin: <20 EU/mg
• Bio-activity: >1.0 x 10^5 IU/mg
• Purity: >95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE.
• Storage Buffer: 10mM Phosphate-Buffered Saline (pH 7.2)
• Storage: Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing.
• Sterility: Sterility
• Instructions: It is recommended that lyophilized GMP rhFGF4 be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration.

Gene Information

• Gene Name: FGF4 fibroblast growth factor 4 [ Homo sapiens (human) ]
• Official Symbol: FGF4
• Synonyms: HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1
• Gene ID: 2249
• mRNA Refseq: NM_002007.4
• Protein Refseq: NP_001998.1
• UniProt ID: P08620
• MIM: 164980