Ubiquitin Carboxyl-terminal Hydrolase 7

• Cat.No.: CBCRY35

Specification

• Cat. No.: CBCRY35
• Background: Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway.
• Protein Classification: Hydrolase
• Structure Weight: 121067.00 Da
• Polymer: 1
• Molecule: Ubiquitin carboxyl-terminal hydrolase 7
• Chain Length: 522 amino acids
• PDB ID: 2F1Z
• MMDB ID: 37695
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 3.2Å
• Reference: Hu, M., Gu, L., Li, M., Jeffrey, P.D., Gu, W., Shi, Y. (2006) Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway. Plos Biol. 4: e27-e27
• Tag: Non

Gene Information

• Gene Name: USP7
• Synonyms: HAUSP; TEF1; EC 3.1.2.15; Herpes virus-associated ubiquitin-specific protease; ubiquitin specific peptidase 7; ubiquitin specific protease 7 (herpes virus-associated); deubiquitinating enzyme 7; Ubiquitin thioesterase 7
• UniProt ID: Q93009
• Gene ID: 7874
• Chromosome Location: 16p13.3
• Function: cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; protein binding; protein C-terminus binding; peptidase activity; cysteine-type peptidase activity; hydrolase activity