XRCC5
-
Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -
Overview
X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells, and reduce drug resistance. -
Synonyms
XRCC5;X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining);X ray repair complementing defective repair in Chinese hamster cells 5 (double strand break rejoining;Ku autoantigen, 80kD);X-ray repair cross-complementing protein 5;KARP 1;Ku autoantigen;80kDa;KU80;Ku86;KUB2;TLAA;CTC85;CTCBF;nuclear factor IV;Ku autoantigen, 80kDa;DNA repair protein XRCC5;thyroid-lupus autoantigen;86 kDa subunit of Ku antigen;lupus Ku autoantigen protein p86;Ku86 autoantigen related protein 1;CTC box-binding factor 85 kDa subunit;ATP-dependent DNA helicase 2 subunit 2;ATP-dependent DNA helicase II 80 kDa subunit;NFIV;KARP1;KARP-1;FLJ39089
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Insect Cell
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&T7
- His&Fc&Avi
- His&MBP
- His&Myc
Involved Pathway
XRCC5 involved in several pathways and played different roles in them. We selected most pathways XRCC5 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-homologous end-joining | MRE11A,POLM,POLL,DCLRE1C,PRKDC,FEN1,XRCC4,NHEJ1,LIG4,DNTT |
Protein Function
XRCC5 has several biochemical functions, for example, contributes_to 5-deoxyribose-5-phosphate lyase activity,ATP binding,ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC5 itself. We selected most functions XRCC5 had, and list some proteins which have the same functions with XRCC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ROS1,INPP5D,PRDM7,MED8,RB1CC1,ZNF460,SBDS,TXNDC9,TARDBP,SPC24 |
| double-stranded DNA binding | IFI203,SAFB,TDG,DDX11,SP1,TDP1,DDX58,GATA1A,AIM2,HES2 |
| damaged DNA binding | ERCC4,TDG,XPA,RPS3,HMGB2,RAD1,RUVBL2,TRP63,TP63,ERCC1 |
| transcription regulatory region DNA binding | Ar,NKX3,NKX2-5,CREB3L2,HOXA13,HDAC1,TP73,HINFP,TA,H2AFY |
| contributes_to double-stranded telomeric DNA binding | XRCC6 |
| ATP binding | CAMK2B1,SBK3,BLM,ADCK1,STRADA,ACTA1A,NEK1,NTRK2B,Fert2,TRIT1 |
| telomeric DNA binding | TEN1,TP53BP1,CDAN1,TERFA,TERT,TERF2,POT1A,CTC1,HNRNPD,TINF2 |
| ubiquitin protein ligase binding | DTX1,HSPA8,UBE2G1,TSG101,TXNIP,GABARAP,HSPA9,GABARAPL1,MAGEA2B,CUL1B |
| protein C-terminus binding | FBLN1,MLLT4,MKI67,DGKZ,PEX16,SLC9A3R2,DLG1,TAX1BP3,VGLL3,LCK |
Interacting Protein
XRCC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC5.
XRCC6;WRN
Resources
Related Services
Related Products
References
