XPNPEP3
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Official Full Name
X-prolyl aminopeptidase (aminopeptidase P) 3, putative -
Overview
The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known. -
Synonyms
XPNPEP3;X-prolyl aminopeptidase (aminopeptidase P) 3, putative;probable Xaa-Pro aminopeptidase 3;APP3;NPHPL1;Aminopeptidase P3;OTTHUMP00000199806;Probable Xaa Pro aminopeptidase 3;X Pro aminopeptidase 3;X prolyl aminopeptidase (aminopeptidase P) 3;X-Pro aminopeptidase 3;XPP3_HUMAN
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
XPNPEP3 involved in several pathways and played different roles in them. We selected most pathways XPNPEP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with XPNPEP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
XPNPEP3 has several biochemical functions, for example, aminopeptidase activity,manganese ion binding,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XPNPEP3 itself. We selected most functions XPNPEP3 had, and list some proteins which have the same functions with XPNPEP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminopeptidase activity | XPNPEP2,XPNPEP1,ERAP2,Npepo,LTA4H,BLMH,DPP9,PEPD,CTSL2,NPEPL1 |
| metallopeptidase activity | HE2,ADAM2,ADAMTSL1,CLCA5,ANPEPB,ENPEP,MMP23B,NPEPPS,ADAM21,MMP14A |
| manganese ion binding | PPEF1,LAP3,HMGCL,PPM1B,NUDT7,PPM1AA,PPM1BB,MRE11A,NPEPL1,PPM1AB |
Interacting Protein
XPNPEP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPNPEP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPNPEP3.
TNFRSF1B;Ubr5;Bub1b;CFTR;MAP1LC3B
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