Wnt5a
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Official Full Name
wingless-type MMTV integration site family, member 5A -
Overview
The Wnt family includes several secreted glycoproteins that play important roles in animal development. There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins. Wnt members bind to the Frizzled family of seven-pass transm -
Synonyms
WNT5A;wingless-type MMTV integration site family, member 5A;protein Wnt-5a;hWNT5A;WNT 5A protein;WNT-5A protein
Recombinant Proteins
- Mouse
- Rat
- Human/Mouse
- Human
- Zebrafish
- Chicken
- E.coli
- CHO
- Mammalian Cell
- L-Wnt-5a-expressing Mouse Fibroblast
- Wheat Germ
- HEK293
- Human Cell
- Mammalian cells
- Yeast
- E. coli
- Insect cell
- In Vitro Cell Free System
- HEK293T
- His&GST
- His
- Non
- GST
- Myc&DDK
- StrepII
- His&Fc&Avi
- Flag
- His&Myc
- His&Myc&SUMO
Involved Pathway
Wnt5a involved in several pathways and played different roles in them. We selected most pathways Wnt5a participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Wnt5a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | FGF9,TRAF5,TCF7L2,PAX8,MLH1,SMAD2,MMP1A,RAC3,FGFR1,IL6 |
| Hedgehog signaling pathway | BMP2,DYRK1A,WNT11B,WNT2,CSNK1G1,RAB23,FBXW11,DHH,IHH,GLI1 |
| HTLV-I infection | BUB3,EP300,FZD3,CREM,BUB1B,VDAC3,SLC25A6,RELA,ANAPC11,SMAD3 |
| Signaling pathways regulating pluripotency of stem cells | APC,LEFTY2,BMI1,WNT2B,PCGF5,PIK3CB,AKT2,BMPR1A,GRB2,FGF2 |
| Hippo signaling pathway | WNT2,WNT5B,STK3,SERPINE1,PPP1CB,SMAD3,WWTR1,RASSF1,LEF1,INADL |
| Basal cell carcinoma | TCF7,PTCH2,DVL2,SUFU,STK36,WNT6,APC,BMP4,WNT7A,DVL1 |
| Proteoglycans in cancer | EZR,WNT3A,ITGAV,IL12B,WNT16,TNF,TIMP3,NANOG,MAPK13,ACTG1 |
| Melanogenesis | MAP2K2,KIT,PRKACBB,WNT16,CALM3A,RAF1A,GNA15.1,GNAI2A,CAMK2A,GSK3B |
| Wnt signaling pathway | RUVBL1,PRKCG,WNT9B,PRKCBA,PRKACAA,PRKACAB,NKD2,CTNNBIP1,PPP3R2,CSNK1A1L |
Protein Function
Wnt5a has several biochemical functions, for example, cytokine activity,frizzled binding,frizzled-2 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Wnt5a itself. We selected most functions Wnt5a had, and list some proteins which have the same functions with Wnt5a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | IRF4A,TBX22,POU3F2A,CREB1,POU4F3,GTF2H4,ZSCAN16,SOX1,KAT7A,THRB |
| transcription regulatory region DNA binding | NR1H3,YAP1,MTERF3,ZFP382,IKZF3,GATA6,CITED1,REST,ZFP639,PAX2 |
| protein domain specific binding | SKIL,SCAF1,HNRNPM,NFE2L2,RQCD1,CALM,STX1B,HMGB2,TACC3,E2F4 |
| frizzled-2 binding | WNT3A |
| cytokine activity | GDF15,FGF2,Ifna15,IL16,IFNG1-1,IFNA6,BMP10,CMTM6,IL5,IL36G |
| receptor agonist activity | CXCL13,WNT4,WNT8A,WNT2,GAS6,WNT3,WNT1,WNT10B,NODAL,GREM1 |
| frizzled binding | WNT7AA,WNT8B,BAMBI,RSPO3,ROR2,WNT4B,WNT8A,WNT7B,WNT2B,WNT16 |
Interacting Protein
Wnt5a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Wnt5a here. Most of them are supplied by our site. Hope this information will be useful for your research of Wnt5a.
FZD5
Wnt5a Related Signal Pathway
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References
- Kikuchi, R; Nakamura, K; et al. An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. NATURE MEDICINE 20:1464-1471(2014).
- Shojima, K; Sato, A; et al. Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. SCIENTIFIC REPORTS 5:-(2015).
