UBE2D1
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Official Full Name
ubiquitin-conjugating enzyme E2D 1 -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] -
Synonyms
UBE2D1;ubiquitin-conjugating enzyme E2D 1;SFT;UBCH5;UBC4/5;UBCH5A;E2(17)KB1;ubiquitin-conjugating enzyme E2 D1;UBC4/5 homolog;stimulator of Fe transport;ubiquitin-protein ligase D1;ubiquitin carrier protein D1;ubiquitin-conjugating enzyme E2(17)KB 1;ubiquitin-conjugating enzyme E2-17 kDa 1;ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- E. coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- GST
- His
- Non
- His&SUMO
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UBE2D1 involved in several pathways and played different roles in them. We selected most pathways UBE2D1 participated on our site, such as Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | MAPK9,DNAJB12A,UBQLN2,PDIA4,CAPN2L,HSP90AA1.1,PDIA3,SEC24D,CUL1A,EIF2AK2 |
| Ubiquitin mediated proteolysis | UBR5,MGRN1,MGRN1B,RHOBTB2,CUL1,ANAPC2,CUL4A,CBLB,UBE2L3A,CUL1A |
Protein Function
UBE2D1 has several biochemical functions, for example, ATP binding,protein binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2D1 itself. We selected most functions UBE2D1 had, and list some proteins which have the same functions with UBE2D1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin conjugating enzyme activity | UBE2Q1,CDC34,UBE2Z,UBE2E3,UBE2E1,UBE2B,UBE2G1,UBE2L3,UBE2QL1,UBE2S |
| ATP binding | CSF1RA,UBE2J1,ABCG3,IPPK,MAPK14B,TAE1,DDX39,HSP104,LIG3,UBE2D4 |
| protein binding | APEX1,CAB39,PARL,SNW1,VPS33B,UBAP1,EFNA1,ARVCF,Fgf15,CCDC103 |
| ubiquitin-protein transferase activity | MARCH5L,FBXL14,MIB2,UBE2D3,PRKCQ,ITCH,FBXL6,MYLIP,RNF5,ARIH1 |
Interacting Protein
UBE2D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2D1.
TRIM39;RNF126;RNF111;RNF5
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References
- Basic, VT; Jacobsen, A; et al. TNF stimulation induces VHL overexpression and impairs angiogenic potential in skeletal muscle myocytes. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:228-236(2014).
- Tokumoto, M; Lee, JY; et al. Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells. JOURNAL OF TOXICOLOGICAL SCIENCES 38:815-820(2013).
