Tlr3
-
Official Full Name
toll-like receptor 3 -
Overview
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
TLR3;toll-like receptor 3;CD283;IIAE2
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Insect Cells
- E.coli
- Mammalian Cells
- HEK293
- C-His
- Human Cells
- His
- Non
- Fc
- hIgG4
- His&S
- GST&His
- Avi&Fc&His
Involved Pathway
Tlr3 involved in several pathways and played different roles in them. We selected most pathways Tlr3 participated on our site, such as Toll-like receptor signaling pathway,Hepatitis C,Hepatitis B, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | PIK3CG,IFNAR1,OAS2,IFNAR2,IFNB1,IRF7,CLDN5,MAPK13,IFN-a,PIK3R2 |
| Hepatitis B | IFNA16,STAT6,APAF1,AKT1,FOS,CREB3L1,IL6,NFKBIA,CREB3L3,BIRC5 |
| Influenza A | IL-8,PIK3CB,IFNGR2,RAF1,PIK3R5,H2-AB1,MAP2K4,EP300,EIF2AK3,BMA2 |
| Toll-like receptor signaling pathway | PIK3R1,TNF,PIK3R3A,IL8L1,MAPK3,IFNA21,IFNB1,CXCL10,STAT1B,IFNA12 |
| Herpes simplex infection | Hc,Ccl12,TP53,TBK1,IFNPHI1,JAK2A,EP300,HLA-DRB5,NXF1,EIF2AK4 |
Protein Function
Tlr3 has several biochemical functions, for example, double-stranded RNA binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr3 itself. We selected most functions Tlr3 had, and list some proteins which have the same functions with Tlr3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded RNA binding | TARBP2,TLR8,ELAVL1,TUBA1B,DGCR8,ILF3,OASL1,MYH4,MBNL1,DICER1 |
| transmembrane signaling receptor activity | GHRHRA,FZD3A,NRXN1,IL11RA,EDAR,NPC1,NRXN2,TLR2-1,AGER,CELSR3 |
| receptor activity | TIGIT,CLEC4E,TLR1,GPA33,CD86,MCC,CD40,CD200R3,AGER,CNTNAP1 |
| identical protein binding | MLL1,SNX16,FHOD1,LRP6,S100A4,SIAH1A,HSPB8,BAK1,LRRK1,ENTPD2 |
| protein binding | DAPK2,CNST,SNX4,SEMA4D,TNNI2,NCOR1,UBE2U,F2,KLK4,MET |
Interacting Protein
Tlr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr3.
PIK3R1;MBL2;SRC;TRIL;CHEK2;TRAF3;TOLLIP
Resources
Research Area
Cancer Drug TargetsNeuroinflammation
Immune Regulatory Molecules on Endothelial Cells
T Cell Antigen Recognition
CD Antigen (Dendritic Cell Lineage Markers)
CD Antigen (Dendritic Cell Pathogen Recognition Uptake)
Macrophage Markers
NOD-like Receptors and the Inflammasome
Toll-Like Receptors (TLRs)
Dendritic Cell Pathogen Recognition/Uptake
Related Services
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References
- Xu, SY; Zhao, YF; et al. Threonine and tryptophan supplementation enhance porcine respiratory and reproductive syndrome (PRRS) vaccine-induced immune responses of growing pigs. ANIMAL SCIENCE JOURNAL 86:294-304(2015).
- Sakuma, C; Sato, M; et al. Anti-WASP intrabodies inhibit inflammatory responses induced by Toll-like receptors 3, 7, and 9, in macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458:28-33(2015).
