TFF1
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Official Full Name
trefoil factor 1 -
Overview
The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. -
Synonyms
TFF1;trefoil factor 1;BCEI, breast cancer, estrogen inducible sequence expressed in;D21S21;HP1.A;HPS2;pNR 2;pS2;protein pS2;polypeptide P1.A;gastrointestinal trefoil protein pS2;breast cancer estrogen-inducible protein;breast cancer estrogen-
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Yeast
- HEK293T
- His&GST
- His&T7
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Fc
Involved Pathway
TFF1 involved in several pathways and played different roles in them. We selected most pathways TFF1 participated on our site, such as FOXA1 transcription factor network,Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FOXA1 transcription factor network | NFIC,CC10,FOXA1,CYP2C18,POU2F1,AP1B1,NRIP1,NFIB,CEBPB,DSCAM |
| Integrated Pancreatic Cancer Pathway | IL11,FKBP1B,GPRC5A,RAPGEF3,BRF1,PPP1R13L,FKBP3,TOP2A,WRN,NOXA1 |
Protein Function
TFF1 has several biochemical functions, for example, growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFF1 itself. We selected most functions TFF1 had, and list some proteins which have the same functions with TFF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | DKK1,FGF20A,FGF5,LEP,TDGF1,AMELX,NRG4,FGF3,FGF18A,CNTF |
| protein binding | FAM128B,CCDC59,RBM15B,IRF8,HDAC3,RDBP,TMEM100,EVI5,HEY1,NUP62L |
Interacting Protein
TFF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TFF1.
ZNF250;BTN3A1;BTNL8;CD300LD;FCRL4;SIGLEC8;XRCC3;FGFR2
Resources
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References
- Seksenyan, A; Kadavallore, A; et al. TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer. BMC CANCER 15:-(2015).
- Shi, LS; Wang, H; et al. Effects of gastrokine-2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways. MOLECULAR MEDICINE REPORTS 10:2898-2904(2014).
