TDO2
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Official Full Name
tryptophan 2,3-dioxygenase -
Overview
Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. -
Synonyms
TDO2;tryptophan 2,3-dioxygenase;TDO;TPH2;3-dioxygenase;T23O_HUMAN;TDO 2;TO;TRPO;Tryptamin 2 3 dioxygenase;Tryptamin 2;Tryptophan 2 3 dioxygenase;Tryptophan 2;Tryptophan oxygenase;Tryptophan pyrrolase;Tryptophanase;tryptamin 2,3-dioxygenase
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cells
- Sf9 Cells
- Yeast
- GST
- His
- DDK&Myc
- Non
- T7
- His&SUMO
- Avi&Fc&His
- Flag
Involved Pathway
TDO2 involved in several pathways and played different roles in them. We selected most pathways TDO2 participated on our site, such as Tryptophan metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | DHCR24,TPH1,MAOA,AOC1,AANAT,OGDHA,OGDHL,OGDH,AANAT2,AADAT |
| Metabolic pathways | TKTB,AOC1,RDH8A,PIGS,OXSR1,CKB,FAXDC2,UCK2,MCAT,AGPAT3 |
Protein Function
TDO2 has several biochemical functions, for example, amino acid binding,heme binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDO2 itself. We selected most functions TDO2 had, and list some proteins which have the same functions with TDO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxygen binding | CYP2AA9,CYP2C54,CYP2D6,CYP2AA4,CYP2X9,CYP2AD6,CYP2K19,HBBE1.1,CYP2K6,HBAA1 |
| heme binding | CYP2K6,HBG2,CYP46A1,CYP19A1,CYP8B3,CYP2C38,CYP2H1,CYP21A1,SDHD,CYP3C4 |
| metal ion binding | YBEY,SCRT2,PPP4C,PITPNM1,BTR18,IRF2BPL,CYP46A1.4,ZFYVE26,PVALB5,ZNF597 |
| tryptophan 2,3-dioxygenase activity | IDO2,TDO2A,TDO2B,IDO1 |
| protein binding | STUB1,CBLB,AGL,PHOSPHO2,PTGDR,TJP2,AAAS,RRAS,TNFRSF10A,SKP1 |
| amino acid binding | DDC,AARS2,KARS,AARS,PAH,TPH2,TPH1A,TPH1,DDAH1,DDAH2 |
Interacting Protein
TDO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDO2.
ASMTL;SDCBP;DPM1;EIF4E;MOB3C;ZFYVE26
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