SERPINI1
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Official Full Name
serpin peptidase inhibitor, clade I (neuroserpin), member 1 -
Overview
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
SERPINI1;serpin peptidase inhibitor, clade I (neuroserpin), member 1;PI12;neuroserpin;neuroserpin;PI-12;serpin I1;peptidase inhibitor 12;serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- HEK293
- E.coli
- Mammalian Cell
- Insect Cell
- Human Cell
- CHO
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
SERPINI1 involved in several pathways and played different roles in them. We selected most pathways SERPINI1 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional activation | HUWE1,DDX18,CDCA7,LIN28B,PDCD10,MINA,PEG10,MTDH,PRDX3,NDUFAF2 |
Protein Function
SERPINI1 has several biochemical functions, for example, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINI1 itself. We selected most functions SERPINI1 had, and list some proteins which have the same functions with SERPINI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | SERPINA3C,SERPINB1L2,SERPINB1C,FURIN,SERPIND1,SERPINA1,SERPINB1L4,CD109,COL28A1,SERPINA1D |
Interacting Protein
SERPINI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINI1.
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