S100B
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Official Full Name
S100 calcium binding protein B -
Overview
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimers disease, Downs syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008] -
Synonyms
S100B;S100 calcium binding protein B;NEF;S100;S100-B;S100beta;protein S100-B;S-100 protein subunit beta;S-100 calcium-binding protein, beta chain;S100 calcium-binding protein, beta (neural)
Recombinant Proteins
- Mouse
- Human
- Canine
- Cattle
- Rabbit
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Bovine
- E.coli
- HEK293
- N-hFc
- Yeast
- Mammalian Cells
- Human
- Human Cells
- Human Brain
- Bovine Brain
- His
- GST
- Fc
- GST&His
- Non
- His&MBP
- DDK&Myc
- Avi&Fc&His
- Avi&His
- Flag
- His&Myc
Involved Pathway
S100B involved in several pathways and played different roles in them. We selected most pathways S100B participated on our site, such as Activated TLR4 signalling,Advanced glycosylation endproduct receptor signaling,Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MyD88 dependent cascade initiated on endosome | S100A12,CHST13,DHX9,ALCAMB |
| Immune System | IFIT10,DEFB4A,TLR6,PELI2,FCGR1B,SOCS3A,ACTR2B,CTSD,MGC174155,BTR09 |
| Activated TLR4 signalling | JUN,UBE2V1,DUSP6,PELI2,SIGIRR,DUSP3B,CREB1,NOD1,AGER,MAPKAPK2B |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | CHST13,APPA,ALCAMB,SAA1,DHX9,APPB,S100A12,AGER |
| MyD88 cascade initiated on plasma membrane | S100A12,AGER,CHST13,TNIP2,PELI3,DHX9,PELI2,TLR10,PELI1,ALCAMB |
| Cytosolic sensors of pathogen-associated DNA | DHX9,TREX1,IFI16,CHST13,ALCAMB,LRRFIP1,APPA,S100A12,POLR3H,CRCP |
| Advanced glycosylation endproduct receptor signaling | APPB,S100A12,SAA1,APPA,LGALS3,ALCAMB,DDOST,AGER |
| Innate Immune System | BTR30,CYLD,CD180,BTR12,DEFB116,POLR3F,DHX9,BAIAP2,FCN2,Txn1 |
Protein Function
S100B has several biochemical functions, for example, RAGE receptor binding,S100 protein binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100B itself. We selected most functions S100B had, and list some proteins which have the same functions with S100B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S100 protein binding | ANXA11,AGER,AHNAK,DDX1,S100A1,EZR,ATP2A2,S100A11,S100A6,FGF1 |
| identical protein binding | GCG,STAT2,FNBP1,UHRF1,MCPH1,KCNJ10,ETNPPL,NUP153,PHYKPL,SERPINB1A |
| protein homodimerization activity | MECOM,HMGCS1,USF1,DMRT2B,TMEM173,ACVR1,SYT14,G6PDX,BCL2L10,MTUS2 |
| RAGE receptor binding | S100A7,HMGB2,S100A4,S100P,HMGB1,S100A9,S100A12,S100A13,FPR1,S100A8 |
| calcium ion binding | ALOX8,CALN1,VIL1,SNCA,ANXA5,SWAP70,NKD2,LRP2,EFCC1,CALRL2 |
| zinc ion binding | MAP3K7IP3,NR5A1,ADAMTS15,MAN2B1,TRIM23,TRIM33,CDADC1,KLF4,CHD4A,FHL1B |
| tau protein binding | DYRK1A,BIN1,PPP2R2A,AATF,SNCA,APOE,SERPINB1A,HDAC6,FKBP4 |
| protein binding | CCDC93,MGAT5B,DUSP21,UBE2D3,MEI4,UBA1,SMN2,NLRC5,ANXA6,DDX11 |
| calcium-dependent protein binding | MASP2,CLEC4M,DMBT1,MMP13,ANXA11,NELF,MBL2,STX1A,VPS37B,ANXA3 |
Interacting Protein
S100B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100B here. Most of them are supplied by our site. Hope this information will be useful for your research of S100B.
S100A1
Resources
Research Area
Calcium-binding Proteins and Related MoleculesGlial Lineage Markers
Neural Progenitor Cell Markers
Related Services
Related Products
References
- Davydov, DM; Lobanov, AV; et al. Neurodevelopment and phenotype-modulating functions of S100B protein: A pilot study. PHYSIOLOGY & BEHAVIOR 140:188-196(2015).
- Travis, TE; Ghassemi, P; et al. A Multimodal Assessment of Melanin and Melanocyte Activity in Abnormally Pigmented Hypertrophic Scar. JOURNAL OF BURN CARE & RESEARCH 36:77-86(2015).
