PPIF
-
Official Full Name
Peptidylprolyl Isomerase F -
Overview
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. -
Synonyms
PPIF;CYP3;Cyp-D;peptidyl-prolyl cis-trans isomerase F, mito-chondrial;PPIase F;rotamase F;cyclophilin 3;cyclophilin D;cyclophilin F;FLJ90798;MGC117207;OTTHUMP00000019925;OTTHUMP00000019926;peptidyl-prolyl cis-trans isomerase, mitochondrial;EC 5.2.1.8;peptidylprolyl isomerase F (cyclophilin F);hCyP3;peptidylprolyl isomerase F
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Human
- Mammalian Cells
- HEK293
- His
- GST
- Non
- T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PPIF involved in several pathways and played different roles in them. We selected most pathways PPIF participated on our site, such as Calcium signaling pathway,Huntingtons disease,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | CHRM2A,LHCGR,PRKACA,TACR3L,NOS2B,CAMK2B,BDKRB1,ITPR1,SLC8A1B,CHRM5 |
| Toxoplasmosis | MAP2K6,HLA-DQA1,LDLR,PIK3R1,NFKBIB,MAPK10,CD40,PIK3CB,GNAI2,LAMA2 |
| cGMP-PKG signaling pathway | PLCB3,ATP1A3,MYH7,CREB5,NFATC2,MYLK3,NOS3,PLCB4,SLC8A2,ATP2A3 |
| Huntingtons disease | UCP1,NDUFAB1,COX7A2,ATP5A1,SOD2,ATP5O,ITPR1,COX6A1,NDUFB6,COX4I1 |
| Parkinsons disease | GNAI2,UBA1,SLC18A2,SEPT5,NDUFA12,SLC18A1,UQCRH,NDUFB6,UQCRC2,APAF1 |
Protein Function
PPIF has several biochemical functions, for example, cyclosporin A binding,peptidyl-prolyl cis-trans isomerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIF itself. We selected most functions PPIF had, and list some proteins which have the same functions with PPIF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidyl-prolyl cis-trans isomerase activity | PPIFA,FKBP8,FKBP10,TTC9C,FKBPL,PPIAL4B,CWC27,PPIL4,PPID,PPIB |
| protein binding | PITX1,TOP2A,IRX1,RALBP1,CACNB4,FNIP1,TPSB2,NEIL2,GRK6,PCGF5 |
| cyclosporin A binding | PPIH,PPIG,PPIC,PPID,PPIE |
Interacting Protein
PPIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIF here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIF.
TP53;BANP;CMTM5;ABI2;C1QBP;C1qbp;ITPR1;BCL2;ATF2
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