Polb
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Official Full Name
polymerase (DNA directed), beta -
Overview
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011] -
Synonyms
POLB;polymerase (DNA directed), beta;DNA polymerase beta;DNA pol beta;mutant DNA polymerase beta;DNA polymerase beta subunit
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- E.coli
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- N-His&C-Myc
- His&Fc&Avi
Involved Pathway
Polb involved in several pathways and played different roles in them. We selected most pathways Polb participated on our site, such as Base excision repair,HTLV-I infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Polb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | CREB3L2,DDX3X,HDAC2,PXN,YWHAB,HLA-F,MAPK1,HIST2H4,GTF2B,CCND2 |
| HTLV-I infection | CD3D,IL2RB,BCL2L1,TBP,CANX,PIK3CG,APC2,TBPL1,TP53INP1,HLA-DRB1 |
| Base excision repair | POLE4,MUTYH,POLE,SMUG1,nth,LIG1,FEN1,HMGB1B,LIG3,PCNA |
Protein Function
Polb has several biochemical functions, for example, DNA-directed DNA polymerase activity,damaged DNA binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Polb itself. We selected most functions Polb had, and list some proteins which have the same functions with Polb. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | RAB11A,KIF18A,MID1,NDEL1A,SERPINB1A,MID2,KIF9,CRIPT,RCC2,GAS2L1 |
| protein binding | IGSF21B,DOK3,COL1A1,EXOC3L,DGCR6L,XRN1,DEFA6,CCDC155,TSC2,RHNO1 |
| metal ion binding | ZFP30,TOP2B,ZXDC,MYLIPB,KIN,DZIP1,CYP2C37,ZNF710A,ZFP524,FHL1B |
| enzyme binding | GSTM4,CRB2,PLCE1,TULP3,HSPA6,POR,TSPAN5,WWOX,ATG3,GSTM7 |
| damaged DNA binding | APTX,DCLRE1C,CRY2,TDG,CREBBP,RAD23AB,RAD18,GTF2H3,APEX1,ERCC3 |
| lyase activity | GUCY2E,ALDOAA,ETNPPL,GLDC,POLL,IRG1L,TYW1,ALDOAB,TYW1B,CBSA |
| DNA-directed DNA polymerase activity | POLM,POLH,PRIMPOL,PAPD7,CHRAC1,CCDC111,MYBBP1A,POLG2,DNTT,POLK |
Interacting Protein
Polb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Polb here. Most of them are supplied by our site. Hope this information will be useful for your research of Polb.
TPP2;XRCC1;TAF1D;SRPK2;KAT7;TLE1;ssdna_dadts;Ktn1;XRCC3;Junb
Resources
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References
Reviews
Efficacy: The enzyme is still active and I am currently using it in some DNA repair assays. It works very well for single nucleotide insertions in gapped DNA which is mostly what I have been using it for recently. Quality: Very happy with the quality and longevity. I think the enzyme is ~1yr old with frequent usage and it is still working fine. Overall Experience: Very happy. When we need more polB/hUNG, and potentially others, we will purchase from you again.
