PCSK5

  • Official Full Name

    proprotein convertase subtilisin/kexin type 5

  • Overview

    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternate splicing results in two variants encoding distinct isoforms, a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, Jan 2014]

  • Synonyms

    PCSK5;proprotein convertase subtilisin/kexin type 5;PC5;PC6;PC6A;SPC6;subtilase;protease PC6;prohormone convertase 5;proprotein convertase 6;subtilisin/kexin-like protease PC5

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • HEK293
  • Yeast
  • His
  • GST
  • Non
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
PCSK5-122H Recombinant Human PCSK5, His-tagged E.coli Human His
PCSK5-121H Recombinant Human PCSK5, GST-tagged Wheat Germ Human GST
PCSK5-30549TH Recombinant Human PCSK5 protein, GST-tagged Wheat Germ Human GST 804-913 a.a.
PCSK5-3370HCL Recombinant Human PCSK5 293 Cell Lysate HEK293 Human Non
PCSK5-1480M Recombinant Mouse PCSK5 Protein (117-452 aa), His-tagged Yeast Mouse His 117-452 aa
PCSK5-4823H Recombinant Human PCSK5 Protein (Asp115-Met454), N-His tagged E.coli Human His Asp115-Met454
PCSK5-711M Recombinant Mouse PCSK5 Protein (117-452 aa), His-SUMO-tagged E.coli Mouse His&SUMO 117-452 aa

    Involved Pathway

    PCSK5 involved in several pathways and played different roles in them. We selected most pathways PCSK5 participated on our site, such as NGF processing,Signal Transduction,Signalling by NGF, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NGF processing FURINB,NTF7,PCSK6,FURINA
    Signalling by NGF PRDM4,ARHGEF1B,DNAL4B,LINGO1,OMG,DNAL4A,PCSK6,RTN4,RIT2,KIDINS220B
    Signal Transduction CCL35.1,PTPRUB,NET1,PYGO1,SOUL3,EVC2,NTS,RBP2A,WDR35,CRABP1A

    Protein Function

    PCSK5 has several biochemical functions, for example, peptidase activity,peptide binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK5 itself. We selected most functions PCSK5 had, and list some proteins which have the same functions with PCSK5. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase activity C1RL,MCPT9,PRSS40,CELA2B,PRSS37,HTRA1,TPSAB1,F9A,KLK1B1,KLK1B24
    peptide binding OXTR,GPR37L1,THOP1,PPIA,AVPR2L,GPR37,CLTB,ANPEPB,H2-Q10,CCKAR
    protein binding KLHL7,ZDHHC13,DMBT1,NAGK,KRT38,MUM1,ATP7B,CYLD,ARL8A,ZNF703
    peptidase activity PSMB8F,OTUD5A,TMPRSS11D,IHHB,ADAM1B,ADAMTS12,CTSJ,KLK1B11,MEP1A.2,PRSS59.1

    Interacting Protein

    PCSK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK5.

    NUFIP2;MEOX2;STK16;GLRX3;KRTAP5-9;KRTAP10-7

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