OPN4
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Official Full Name
opsin 4 -
Overview
visual pigment of phototransducing retinal ganglion cells involved in setting the circadian clock -
Synonyms
OPN4;opsin 4;opsin 4 (melanopsin);melanopsin;MOP;opsin-4;MGC142118
Recombinant Proteins
- Chicken
- Rat
- Human
- Rutilus rutilus (Roach)
- Podarcis siculus (Italian wall lizard)
- Branchiostoma belcheri (Amphioxus)
- Felis catus
- Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster)
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| OPN4-3445C | Recombinant Chicken OPN4 | Mammalian Cells | Chicken | His |
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| OPN4-4192R | Recombinant Rat OPN4 Protein | Mammalian Cells | Rat | His |
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| OPN4-806H | Recombinant Human OPN4 | Mammalian Cells | Human | His |
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| OPN4-3574HCL | Recombinant Human OPN4 293 Cell Lysate | HEK293 | Human | Non |
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| Opn4-10254R | Recombinant Rat Opn4 Full Length Transmembrane protein, His-tagged | E.coli | Rat | His | Full L. 1-474aa |
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| OPN4-3732H | Recombinant Human OPN4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| OPN4-3732H-B | Recombinant Human OPN4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| OPN4-3854R | Recombinant Rat OPN4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| OPN4-3854R-B | Recombinant Rat OPN4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL13891RF | Recombinant Full Length Rutilus Rutilus Melanopsin(Opn4) Protein, His-Tagged | E.coli | Rutilus rutilus (Roach) | His | Full L. Full Length (1-500) |
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| RFL18949PF | Recombinant Full Length Podarcis Sicula Melanopsin(Opn4) Protein, His-Tagged | E.coli | Podarcis siculus (Italian wall lizard) | His | Full L. Full Length (1-475) |
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| RFL20247BF | Recombinant Full Length Branchiostoma Belcheri Melanopsin(Opn4) Protein, His-Tagged | E.coli | Branchiostoma belcheri (Amphioxus) | His | Full L. Full Length (1-706) |
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| RFL26701FF | Recombinant Full Length Cat Melanopsin(Opn4) Protein, His-Tagged | E.coli | Felis catus | His | Full L. Full Length (1-487) |
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| RFL2917PF | Recombinant Full Length Phodopus Sungorus Melanopsin(Opn4) Protein, His-Tagged | E.coli | Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster) | His | Full L. Full Length (1-469) |
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| RFL471MF | Recombinant Full Length Mouse Melanopsin(Opn4) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length (1-521) |
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| RFL5284RF | Recombinant Full Length Rat Melanopsin(Opn4) Protein, His-Tagged | E.coli | Rat | His | Full L. Full Length (1-474) |
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| RFL7046HF | Recombinant Full Length Human Melanopsin(Opn4) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-478) |
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Involved Pathway
OPN4 involved in several pathways and played different roles in them. We selected most pathways OPN4 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with OPN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | OTULIN,ADH8A,NPS,PDE10A,ARHGAP17B,DNAL4,PAG1,EMR4,GPR132,NET1 |
| GPCR downstream signaling | NMB,CCR8,ABR,OPN5,AKAP13,CRHR1,GPR132,OR52B4,OPN1MW2,NPFFR2 |
| G alpha (q) signalling events | GPRC6A,QRFPR,PRKCHB,EDN1,UTS2,TRPC6A,LPAR2A,KALRNB,NMB,NPS |
| Gastrin-CREB signalling pathway via PKC and MAPK | ANXA1B,OPN4A,GPR132B,FPR-RS6,TAC1,LPAR1,TAE1,PROK1,DGKQ,GPR132 |
| GPCRs, Class A Rhodopsin-like | GPR20,FPR-RS4,CCRL2,CCR7,OPN3,GPR3,PTGDR2,SSTR4,GPR63,CCR9 |
| GPCR ligand binding | OXGR1A.2,GNB5A,OPN4A,OPN1MW,OPN1SW1,EDNRA,OPN1LW2,LTB4R,RGR,RAMP3 |
| Opsins | OPN4.1,RGS1,OPN5,RGR,OPN1LW1,OPN1LW2,OPN1SW1,OPN4B,OPN4A |
| Class A/1 (Rhodopsin-like receptors) | LPAR2A,ADORA3,AMCF-II,CCL35.2,QRFP,INSL5,NMU,NMB,UTS2D,TAC1 |
Protein Function
OPN4 has several biochemical functions, for example, 11-cis retinal binding,G-protein coupled photoreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OPN4 itself. We selected most functions OPN4 had, and list some proteins which have the same functions with OPN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled photoreceptor activity | GNAT3,EXORH,OPN4A,GNAT2 |
| 11-cis retinal binding | RLBP1,OPN5 |
Interacting Protein
OPN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OPN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of OPN4.
Resources
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References
- Kang, SW; Leclerc, B; et al. MELANOPSIN EXPRESSION IN DOPAMINE-MELATONIN NEURONS OF THE PREMAMMILLARY NUCLEUS OF THE HYPOTHALAMUS AND SEASONAL REPRODUCTION IN BIRDS. NEUROSCIENCE 170:200-213(2010).
- Pires, SS; Hughes, S; et al. Differential Expression of Two Distinct Functional Isoforms of Melanopsin (Opn4) in the Mammalian Retina. JOURNAL OF NEUROSCIENCE 29:12332-12342(2009).
- Kubo, Y; Akiyama, M; et al. Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal glandnn. JOURNAL OF NEUROCHEMISTRY 97:1155-1165(2006).
