NUDT3

  • Official Full Name

    nudix (nucleoside diphosphate linked moiety X)-type motif 3

  • Overview

    NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998

  • Synonyms

    NUDT3;nudix (nucleoside diphosphate linked moiety X)-type motif 3;diphosphoinositol polyphosphate phosphohydrolase 1;DIPP;Diadenosine 5 5 P1 P6 hexaphosphate hydrolase 1;Diphosphoinositol polyphosphate phosphohydrolase;DIPP 1;DIPP1;Nucleoside diphosphate linked moiety X motif 3;Nudix (nucleoside diphosphate linked moiety X) type motif 3;Nudix motif 3;Nudix type motif 3;NUDT 3;OTTHUMP00000016227;nucleoside diphosphate-linked moiety X motif 3;diadenosine 5,5-P1,P6-hexaphosphate hydrolase 1;DIPP-1

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
NUDT3-1406H Recombinant Human NUDT3, GST-tagged E.coli Human GST 1-172aa
NUDT3-10974M Recombinant Mouse NUDT3 Protein Mammalian Cells Mouse His
NUDT3-27534TH Recombinant Human NUDT3, His-tagged E.coli Human His 172 amino acids
NUDT3-3128R Recombinant Rhesus monkey NUDT3 Protein, His-tagged Mammalian Cells Rhesus macaque His
NUDT3-3476H Recombinant Human NUDT3, His-tagged E.coli Human His
NUDT3-4118R Recombinant Rat NUDT3 Protein Mammalian Cells Rat His
NUDT3-4619C Recombinant Chicken NUDT3 Mammalian Cells Chicken His
NUDT3-1227HCL Recombinant Human NUDT3 cell lysate Human Non
NUDT3-2946R Recombinant Rhesus Macaque NUDT3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
NUDT3-2946R-B Recombinant Rhesus Macaque NUDT3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
NUDT3-30117H Recombinant Human NUDT3 protein, GST-tagged E.coli Human GST Met1-Arg172
NUDT3-3144H Recombinant Human NUDT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
NUDT3-376H Recombinant Human NUDT3 protein, His-tagged E.coli Human His 1-172 aa
NUDT3-3779R Recombinant Rat NUDT3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
NUDT3-3779R-B Recombinant Rat NUDT3 Protein Pre-coupled Magnetic Beads HEK293 Rat
Nudt3-4541M Recombinant Mouse Nudt3 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
NUDT3-6258M Recombinant Mouse NUDT3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
NUDT3-6258M-B Recombinant Mouse NUDT3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    NUDT3 involved in several pathways and played different roles in them. We selected most pathways NUDT3 participated on our site, such as Inositol phosphate metabolism,Metabolism,Synthesis of pyrophosphates in the cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism MIOX,SYNJ1,INPP5A,PTEN,PI4K2A,PLCB1,MINPP1A,PIK3CB,INPP5J,MTMR8
    Metabolism MED23,SLC52A3,COX15,CETP,SLC2A3,CDS1,Alb,PDK2B,KCNS3A,APOBB.1
    Synthesis of pyrophosphates in the cytosol NUDT3A,IP6K3,NUDT11,NUDT4A,NUDT10,NUDT3B,NUDT4B,NUDT4

    Protein Function

    NUDT3 has several biochemical functions, for example, diphosphoinositol-polyphosphate diphosphatase activity,inositol diphosphate tetrakisphosphate diphosphatase activity,inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT3 itself. We selected most functions NUDT3 had, and list some proteins which have the same functions with NUDT3. You can find most of the proteins on our site.

    Function Related Protein
    magnesium ion binding ATP11C,SRPK1,NT5C3A,MAP3K8,NT5C3L,TREX2,NT5C3B,PKLR,RPS6KA3B,ARF1
    inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity NUDT10,NUDT4,NUDT11
    inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity NUDT4,NUDT11,NUDT10
    inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity NUDT4,NUDT11,NUDT10
    inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity NUDT10,NUDT4,NUDT11
    diphosphoinositol-polyphosphate diphosphatase activity NUDT4,NUDT10,NUDT11
    inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity NUDT11,NUDT10,NUDT4
    inositol diphosphate tetrakisphosphate diphosphatase activity NUDT4,NUDT11,NUDT10
    inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity NUDT4,NUDT11,NUDT10

    Interacting Protein

    NUDT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT3.

    RPLP1;ASB13;PDCD5;PRKD3;SOX30;OAT;NR2C1;ALAS1;RPL17;EEF1G;APEX1;DNAJA1;MCM5;TNNT3;PEX5;CCL11;RPL8;REEP5

    Resources

    References

    • Albayrak, O; Putter, C; et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 162B:295-305(2013).
    • Wilson, GRS; Morton, JD; et al. The locus for an inherited cataract in sheep maps to ovine chromosome 6. MOLECULAR VISION 18:1384-1394(2012).

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