NOX1
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Official Full Name
NADPH oxidase 1 -
Overview
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NOX1;NADPH oxidase 1;GP91 2;mitogenic oxidase (pyridine nucleotide dependent superoxide generating);MOX1;NADPH oxidase 1 variant NOH 1L;NADPH oxidase homolog 1;NOH 1;NOH1;MOX-1;NOX-1;mitogenic oxidase 1;NADPH oxidase homolog-1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
NOX1 involved in several pathways and played different roles in them. We selected most pathways NOX1 participated on our site, such as HIF- signaling pathway,Phagosome,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | GM5506,ANGPT4,PIK3R3,IL6,MAPK3,INSR,ANGPT2,RPS6KB1,NOS3,IFNGR2 |
| Leukocyte transendothelial migration | ACTN1,JAM3,CLDN14,ESAM,CLDN18,VASP,MMP9,CLDN3,NCF1,MYL5 |
| Phagosome | TUBA1B,ITGB1,FAM49BA,MHC1UEA,TLR2,CD209A,STX12,TUBA3B,CTSLA,TUBB6 |
| Osteoclast differentiation | LILRA5,LILRB5,CALCR,AKT2,TGFBR1,CAMK4,LILRB3,IKBKB,LILRA1,RELB |
Protein Function
NOX1 has several biochemical functions, for example, NADP binding,Rac GTPase binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX1 itself. We selected most functions NOX1 had, and list some proteins which have the same functions with NOX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | DOCK4,NOXA1,DVL1,RCC2,SRGAP2A,CORO1C,SOD1,PKN1,PAK3,SRGAP3 |
| voltage-gated proton channel activity | HVCN1 |
| protein binding | STRADB,SNRPD3,ZNF69,MICAL1,PHF21A,GALR1,FHL3,RCOR1,GOLSYN,BDKRB2 |
| metal ion binding | BTR16,RFK,ZFP574,HDAC5,SPON2,CA4A,UNC13A,CYP4A10,GPHN,FBP1 |
| superoxide-generating NADPH oxidase activity | NOX4,NOX3,PAX2,SH3PXD2AA,NCF1,CYBB,NOX5 |
| NADP binding | GAPDH,CRYM,FMO1,NOS3,NOX5,ME1,CAT,HMGCRB,ASPDH,MIOX |
Interacting Protein
NOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOX1.
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References
- Matsumoto, M; Katsuyama, M; et al. Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase. FREE RADICAL BIOLOGY AND MEDICINE 68:196-204(2014).
- Ren, RD; Azuma, Y; et al. Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects. BRITISH JOURNAL OF NUTRITION 110:880-890(2013).
