NGFR
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Official Full Name
nerve growth factor receptor -
Overview
receptor that can bind NGF, BDNF, NT-3, and NT-4 [RGD, Feb 2006] -
Synonyms
NGFR;nerve growth factor receptor;p75;LNGFR;p75NTR;RNNGFRR;Tnfrsf16;tumor necrosis factor receptor superfamily member 16;p75 ICD;gp80-LNGFR;NGF receptor;nerve growth factor receptor, fast;low affinity nerve growth factor receptor;low affinity neurotrophin receptor p75NTR;low-affinity nerve growth factor receptor;nerve growth factor receptor (TNFR superfamily, member 16)
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rabbit
- Rat
- Human Cell
- HEK293
- CHO
- Mammalian cells
- Mammalian Cell
- Insect Cell
- E.coli
- HEK293T
- E.coli expression system
- Fc
- Non
- hIgG4
- His
- His&Avi
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NGFR involved in several pathways and played different roles in them. We selected most pathways NGFR participated on our site, such as Ras signaling pathway,Rap signaling pathway,Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NGFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PIK3R2,PIK3CA,FGF17,Il4ra,HRAS,PIK3CG,TEK,MTCP1,KITLG,IFNAR2 |
| Cytokine-cytokine receptor interaction | BMPR2A,CCL23,CX3CL1,GM13305,IFNL3,TGFB1A,IFNA10,Il4ra,KDR,TNFRSF14 |
| Neurotrophin signaling pathway | IRAK4,MAP2K5,CALM2,ATF4,BDNF,PRDM4,SH2B2,ARHGDIA,NTRK2,ARHGDIB |
| Rap signaling pathway | ANGPT4,PARD6B,PDGFC,FGF7,FPR1,KITLG,PRKCA,FGF6,GNAI2,PDGFA |
| Ras signaling pathway | PDGFD,PLA2G6,ABL1,GNG12,RAC2,MAP2K1,MLLT4,LOC608458,ABL2,RASAL1 |
| Transcriptional misregulation in cancer | ETV5,MET,CCNT1,DEFA3,HIST1H3H,HIST2H3C1,ASPSCR1,FLT3,IL1R2,HIST2H3A |
Protein Function
NGFR has several biochemical functions, for example, Rab GTPase binding,beta-amyloid binding,death receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NGFR itself. We selected most functions NGFR had, and list some proteins which have the same functions with NGFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neurotrophin binding | NTRK2,NTRK3,NTRK1 |
| protein binding | CCNK,SH3GL3,ADAT2,PRDM10,TDGF1,TIRAP,Arid4b,EIF4E2,YIPF2,APPB |
| Rab GTPase binding | RILP,ANKRD27,ULK1,RPH3A,RAB11FIP3,RABGEF1,MLPHB,RAB11FIP5,RAB11FIP4B,GAS8 |
| tumor necrosis factor-activated receptor activity | CD40,TNFRSF4,RELT,TNFRSF14,TNFRSF6B,TNFRSF10B,TNFRSF9,TNFRSF11A,TNFRSF10C,TNFRSF10D |
| death receptor activity | TNFRSF10A |
| neurotrophin TRKA receptor binding | FRS2,PLCG1,PIK3R1,EFNA5,GRB2,SHC1 |
| beta-amyloid binding | APBA3,COL25A1,OLFM1,HBA-A2,BCHE,FBXO2,LDLRAP1,BACE2,APBB2,APOA1 |
| nerve growth factor binding | FURIN,PCSK6,NGFRB,NTRK1,SORT1 |
| ubiquitin protein ligase binding | MOAP1,CUL3B,BID,ERLIN2,TMEM189,TRAF5,UBE2G1,RNF34,TRIB2,RAD18 |
Interacting Protein
NGFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NGFR here. Most of them are supplied by our site. Hope this information will be useful for your research of NGFR.
NGFR Related Signal Pathway
Resources
Research Area
Cytokine and Growth Factor Receptors on VSMCNogo Proteins and Receptors
Neurotrophin/Trk Family
VPS10P-domain Family
Mesenchymal Stem Cell Markers
Glial Lineage Markers
Neural Crest Cell Markers
Neurotrophin Receptor
TNF Receptor
Melanoma Cancer Stem Cell Markers
Mesodermal Lineage Markers
Breast Cancer Biomarkers
Related Services
Related Products
References
- Suzuki, N; Takata, M; et al. Assessment of Melanoma-Initiating Cell Markers and Conventional Parameters in Sentinel Lymph Nodes of Malignant Melanoma. ACTA MEDICA OKAYAMA 69:17-27(2015).
- Murillo-Sauca, O; Chung, MK; et al. CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma. ONCOTARGET 5:6854-6866(2014).
