MYL12B
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Official Full Name
myosin, light chain 12B, regulatory -
Overview
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments. -
Synonyms
MLC-B;MRLC2;myosin regulatory light chain 12B;MLC-2;MLC20;MLC-2A;SHUJUN-1;OTTHUMP00000162244;OTTHUMP00000165806;OTTHUMP00000165807;OTTHUMP00000165808;myosin regulatory light chain 2;myosin regulatory light chain MRLC2;myosin regulatory light chain 20 kDa;myosin regulatory light chain 2-B, smooth muscle isoform;MYL12B;myosin, light chain 12B, regulatory
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- His&T7
- Myc&DDK
- His&Fc&Avi
- GST
- N-His-GST
Involved Pathway
MYL12B involved in several pathways and played different roles in them. We selected most pathways MYL12B participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | PTK2B,CLDN14,ROCK2,PIK3R1,CLDN6,ITGAM,OCLN,ARHGAP35,PIK3CD,AASS |
| EPHA-mediated growth cone collapse | MYL9,EFNA5,EPHA4A,EFNA2A,EPHA10,EFNA3,KDR,SHB,EFNA4,EFNA1B |
| Axon guidance | EFNA5,DNM1,ANK2B,NTN1A,TRIO,PAK6,CSNK2B,SEMA3G,AP2S1,GFRA2 |
| EPH-Ephrin signaling | ACTR3,CLTC,AP2B1,EPHB4B,ARHGEF28,EFNA2A,ARPC2,ARPC1B,ARPC3,EFNB2A |
| Muscle contraction | TNNI2A.4,VIML,TMOD1,TNNT3,TNNT3B,LMOD1,TMOD3,MYBPC2B,TNNI1,MYL9 |
| Platelet activation | ARHGEF12,FGB,F2RL3,AKT1,PLCB4,PRKCZ,PRKCI,PIK3R5,GP6,ACTG1 |
| Developmental Biology | FOXH1,DNM2,RHOB,AP2M1,DUSP5,MED16,CSNK2B,UNC5D,SCN2B,PHB |
| Focal adhesion | ITGA8,MAPK9,ITGA11A,ACTB1,RAC3B,COL2A1A,TLN2A,PPP1CAA,PAK2,GSK3AA |
Protein Function
MYL12B has several biochemical functions, for example, calcium ion binding,myosin heavy chain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL12B itself. We selected most functions MYL12B had, and list some proteins which have the same functions with MYL12B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| myosin heavy chain binding | MYL2,MYL9,PDLIM2,CORO1A,MYBPC3,AMPD1 |
| calcium ion binding | PADI2,FAT1A,PCDH2AB6,MMP24,SYT5B,MYLZ3,CALR3B,CCDC102A,EMR1,DLK2 |
| protein binding | RARB,GDPD5,VAPA,LSM3,TMEM88,UBE2L3,PHF23,CKM,GAGE1,FAM156A |
Interacting Protein
MYL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL12B.
ACTB;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;DAPK3;ACTA2;MYH11;USP45;HSPB1;q81ws3_bacan;FN1;VCAM1;ARRB1;GRB2;GTF2B;BECN1
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