MYBPC3
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Official Full Name
myosin binding protein C, cardiac -
Overview
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] -
Synonyms
MYBPC3;myosin binding protein C, cardiac;FHC;CMH4;CMD1MM;LVNC10;MYBP-C;myosin-binding protein C, cardiac-type;C-protein, cardiac muscle isoform
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- E. coli
- E.coli
- HEK293
- Mammalian Cells
- Yeast
- His
- SUMO
- DDK
- Myc
- GST
- Avi
- Fc
- Flag
Involved Pathway
MYBPC3 involved in several pathways and played different roles in them. We selected most pathways MYBPC3 participated on our site, such as Dilated cardiomyopathy,Hypertrophic cardiomyopathy (HCM),Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYBPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | ITGB5,RYR2,PRKAA2,TGFB1,CACNG4,TGFB2,SGCA,TNNI3,ITGB4,ACTC1 |
| Dilated cardiomyopathy | Adcy4,CACNG8,ITGB4,ITGA2B,ITGA7,LAMA2,EMD,SGCA,ITGB3,CACNB1 |
| Muscle contraction | TNNI2B.1,ANXA2,MYL6B,TMEM8C,TNNI1B,MYL12B,TMOD1,SMYHC3,MYLZ3,MYL1 |
| Striated Muscle Contraction | MYL1,SMYHC3,DESMA,TNNT3,TNNT1,DMD,SMYHC2,CMLC1,TNNI2A.4,TMOD2 |
Protein Function
MYBPC3 has several biochemical functions, for example, ATPase activator activity,actin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYBPC3 itself. We selected most functions MYBPC3 had, and list some proteins which have the same functions with MYBPC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RIMS2,MC5R,TNFRSF6B,CYP1A1,IKBKB,DNMBP,RPL11,RBM25,ULK2,SLC5A1 |
| identical protein binding | BTK,CD247,COL18A1,PLDN,STAT6,CLDN23,FBLN1,ATF3,SOD2,AKT1 |
| titin binding | ANKRD1,SLC14A2,CALM,ANKRD23,ACTN2,ANKRD1B,CALM1,CAPN3,CALM2,TCAP |
| ATPase activator activity | DNAJB1,AHSA2,TOR1AIP1,TOR1AIP2,DNAJC24,AHSA1L,DNAJC10,DNAJC15,RAB4A,DNAJB6 |
| myosin heavy chain binding | MYL12B,MYL9,AMPD1,MYL2,CORO1A,PDLIM2 |
| metal ion binding | RNF11A,HBB-BH1,PPP3CC,NUDT17,Gh,ZDHHC24,ZNF37A,EXTL2,ZC3H14,ZHX3 |
| actin binding | SHROOM4,NF2A,SMTN,SHROOM1,MYH15,NF2,NRAP,ACTR2A,MSN,FRG1 |
| myosin binding | GIPC1,RHOA,TRIM32,ARFGEF2,CALD1B,USH2A,SMYD1B,ACTA1,DMD,VEZT |
| structural constituent of muscle | TPM2,DMD,MYL6,NEBL,COX4I2,SYNM,TTN,PLEC,MYLPF,MYL2 |
Interacting Protein
MYBPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYBPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYBPC3.
PDE4DIP;SVIL;MYZAP;CNN1;ACTB;ACTC1;FLNC;TNNI3K;SPATA20;PARD3;TRIM63;CCT7;SMURF2
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