MVP
-
Official Full Name
major vault protein -
Overview
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. -
Synonyms
MVP;major vault protein;LRP;lung resistance related protein;VAULT1;lung resistance-related protein
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- Methanocaldococcus jannaschii
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- His&T7
- Non
- Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
MVP involved in several pathways and played different roles in them. We selected most pathways MVP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MVP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MVP has several biochemical functions, for example, protein binding,protein kinase binding,protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MVP itself. We selected most functions MVP had, and list some proteins which have the same functions with MVP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase binding | PPME1,PPP1R3C,LCK,STAT3,DLG3,RPA3,VRK3,TRAF3,JAK1,CDC27 |
| protein binding | PLN,STARD3,DYNLT1,DCTN3,IRF2BP1,ASCL4,PRDM7,ANLN,IL10RB,ANXA5 |
| protein kinase binding | CCNL1,GDF3,PRKACA,GPRC5B,CAMK2N1,SLC12A5,LAX1,CALM,PDGFRB,ZC3HC1 |
Interacting Protein
MVP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MVP here. Most of them are supplied by our site. Hope this information will be useful for your research of MVP.
PLSCR1;YWHAZ;MT-CYB;HP;EPHX2;KPNA2;CKAP4;NNT;GIT2;q7cl30_yerpe;deoB;yhdL;clpB;q81za2_bacan;POT1;q9wmx2-pro_0000037548;pi3p
Resources
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References
- Cai, M; Zhu, F; et al. Expression, purification and glycosylation analysis of chicken infectious bursal disease virus VP2 in yeast. IRANIAN JOURNAL OF VETERINARY RESEARCH 14:211-219(2013).
- Termine, C; Trotti, R; et al. Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. ACTA NEUROLOGICA SCANDINAVICA 122:91-96(2010).
