MPO
-
Official Full Name
myeloperoxidase -
Overview
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008] -
Synonyms
MPO;myeloperoxidase
Recombinant Proteins
- Human
- Mouse
- Rat
- Cattle
- E.coli
- Mammalian Cells
- Human Sputum
- Neutrophils
- NS0
- HEK293
- Human Cells
- Insect Cells
- Wheat Germ
- Human Neutrophil
- Non
- His
- T7
- GST
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
MPO involved in several pathways and played different roles in them. We selected most pathways MPO participated on our site, such as Phagosome,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | RAC1B,ATP6V0E,HLA-E,FCGR4,ITGB2L,LAMP2,TUBB2B,MBL1,M6PR,CD209C |
| Transcriptional misregulation in cancer | GRIA3,TFE3,TCF3,PBX1,LMO2,HIST2H3A,MLLT3,ASPSCR1,IGF1,HIST1H3C |
Protein Function
MPO has several biochemical functions, for example, chromatin binding,heme binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MPO itself. We selected most functions MPO had, and list some proteins which have the same functions with MPO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | CCL15,F11,VTN,COL20A1,FGF14,RPL22,PTPRF,PCSK6,PGF,NRP1A |
| peroxidase activity | MGST3,GPX7,PXDN,PTGS2A,EPX,PRDX5,GPX1A,GPX5,GPX4A,IPCEF1 |
| metal ion binding | ZNF395B,ZDHHC24,ZNF549,PPTC7,GNAT2,IREB2,ADARB2,THAP4,KLF12,WDFY3 |
| chromatin binding | ZKSCAN3,BAHD1,NR5A5,CSNK2B,COQ7,APBB1,CBX1,ISL1,TPR,CAPNS2 |
| heme binding | CYBB,HBG1,EIF2AK1,SUOX,NOS3,HBAE3,IDO1,CYP46A1.1,CYP2P9,GUCY1A3 |
Interacting Protein
MPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPO here. Most of them are supplied by our site. Hope this information will be useful for your research of MPO.
Dynll1;ssrna_ug
Resources
Research Area
Myeloid Lineage MarkersGranulocyte Markers
Multiple Sclerosis and Myelin Related Molecules
Neutrophils
CD Antigen (Granulocyte Markers)
Related Services
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References
