MED22
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Official Full Name
mediator complex subunit 22 -
Overview
This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
MED22;mediator complex subunit 22;SURF5, surfeit 5;mediator of RNA polymerase II transcription subunit 22;Med24;MED22_HUMAN;OTTHUMP00000022480;OTTMUSP00000012503;RGD1564893;Surf 5;Surf-5;Surfeit 5;Surfeit locus protein 5;SURF5
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
MED22 involved in several pathways and played different roles in them. We selected most pathways MED22 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED18,MED26,MED16,MTF1,MED29,ANKRD1,CTGF,GRHL1,GLIPR1,CDK19 |
| PPARA activates gene expression | MED20,TIAM2,MED23,MED18,PLIN2,SREBF2,MED25,MED26,MED10,MED31 |
| Developmental Biology | TRPC3,DUSP5,FRS2B,CNTN6,CEBPA,CDH4,EPHB3A,INSM1A,NR2F2,UNC5D |
| Metabolism | SLC25A14,IDO2,KCNG4,FA2H,AKR1B15,CDO1,GPHN,Sult2a6,MED15,CHKA |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACOT7,CYP7A1,ACOT9,MED21,CDK19,ESRRA,STIL,ACSF2,MED16,ACOT11 |
| Transcriptional regulation of white adipocyte differentiation | EGR2,MED9,CDK19,NR2F2,MED21,MED19,MED18,EBF1,MED29 |
| Metabolism of lipids and lipoproteins | ACOT11A,AKR1C4,OSBP,CHKB,PTGDSA,CYP8B2,NFYBA,ECI1,SLC27A2,THEM5 |
Protein Function
MED22 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED22 itself. We selected most functions MED22 had, and list some proteins which have the same functions with MED22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED13A,MED13B,MED19A,MED13,MED11,TP53BP1,MED7,MED20,RBM14,MED4 |
| protein binding | TUBGCP2,BRIP1,THAP11,CCL7,SEC22B,KCTD17,FAM92A,ZMAT3,MEF2D,HSPA6 |
Interacting Protein
MED22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED22.
MED10;MED29;Med30;MED19;MED27
Resources
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References
- Tebbji, F; Chen, YL; et al. A Functional Portrait of Med7 and the Mediator Complex in Candida albicans. PLOS GENETICS 10:-(2014).
- Seizl, M; Lariviere, L; et al. Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. NUCLEIC ACIDS RESEARCH 39:6291-6304(2011).
