MAP4K1

  • Official Full Name

    mitogen-activated protein kinase kinase kinase kinase 1

  • Overview

    Hematopoietic progenitor kinase 1(HPK1) is a member of the germinal center kinases that is predominantly expressed in hematopoietic cells. HPK1 is a key component linking T or B cell receptors to SAPK/JNK and IkappaB kinase pathways in lymphocytes. Throug

  • Synonyms

    MAP4K1;mitogen-activated protein kinase kinase kinase kinase 1;hematopoietic progenitor kinase 1;HPK1;MEKKK 1;MEK kinase kinase 1;MAPK/ERK kinase kinase kinase 1

Recombinant Proteins

  • Human
  • Monkey
  • Dog
  • Rat
  • Mouse
  • Sf9 Insect Cell
  • Insect Cell
  • Insect cells
  • E. coli
  • GST
  • His
  • Non
  • N-Twin strep and C-His&Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAP4K1-1041H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, GST-tagged Sf9 Insect Cell Human GST 1-346 a.a.
MAP4K1-03M Recombinant Monkey MAP4K1 Protein, C-His tagged Insect Cell Monkey His
MAP4K1-04D Recombinant Dog MAP4K1 Protein, GST tagged Insect Cell Dog GST
MAP4K1-05R Recombinant Rat MAP4K1 Protein, C-His tagged Insect Cell Rat His
MAP4K1-27602TH Recombinant Human MAP4K1 Sf9 Insect Cell Human Non 346 amino acids
Map4k1-9520M Active Recombinant Mouse Map4k1 Protein, GST-tagged Insect cells Mouse GST 1-346 a.a.
MAP4K1-135H Recombinant Human mitogen-activated protein kinase kinase kinase kinase 1 Protein, His&Flag&StrepII tagged E. coli Human N-Twin strep and C-His&Flag 324-457aa
MAP4K1-79H Recombinant Human MAP4K1 Protein, GST-tagged Insect cells Human GST

    Involved Pathway

    MAP4K1 involved in several pathways and played different roles in them. We selected most pathways MAP4K1 participated on our site, such as B Cell Receptor Signaling Pathway,BCR signaling pathway,Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by Stem cell factor receptor (c-Kit) STAP1,EVLA,PTPRO,SH2B3
    B Cell Receptor Signaling Pathway LYN,PILRB,PRKCB,IGHM,NFKBIE,ARPC3,ARPC1B,RAP2A,CD81,AKT1
    BCR signaling pathway DOK1,CSNK2A1,CSK,MALT1,PAG1,POU2F2,NETO2,IBTK
    JNK signaling in the CD4+ TCR pathway DBNL
    Prostate Cancer INSRR,TRP53,IKBKG,BAD,PTEN,SOS1,PDGFA,NKX3-1,PDGFC,MAP2K2
    Insulin Signaling SNAP25A,MYO1C,INPP4AA,MAPK6,FLOT1,ARHGAP33,STXBP3A,MAP3K2,CAP1,MAP4K5
    MAPK signaling pathway CACNB2,NRAS,MINK1,PDGFB,NFATC3,TAOK3,PRKACG,NR4A1,RRAS2,PPM1AB

    Protein Function

    MAP4K1 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K1 itself. We selected most functions MAP4K1 had, and list some proteins which have the same functions with MAP4K1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding KPNA4,BANP,CMTM2A,ZKSCAN17,SH2D2A,FH,ZNF69,ACTN3,GZMA,GOLGA3
    protein kinase activity ERBB3A,MAP2K4A,TSSK5,PRKACAA,COL4A3BP,PDK3,RIPK1L,MINK1,NRBP2,PLK5
    protein serine/threonine kinase activity LATS1,PRKCDA,PAK6,BRAF,MAP3K10,SGK2,ROCK1,PHKG1B,STK4,RIPK2
    ATP binding TTF2,NSFB,RECQL4,PCCA,ABCG2B,NADK2,UBE2U,KALRN,SRPK2,PFAS
    MAP kinase kinase kinase kinase activity MAP4K2,MAP4K3,MAP4K6,ALPK2,MAP4K5

    Interacting Protein

    MAP4K1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K1.

    GRB2;PLCG1;NCK1;CRK

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