KCNJ4

  • Official Full Name

    potassium inwardly-rectifying channel, subfamily J, member 4
  • Overview

    Various potassium channels are involved with electrical signaling in the nervous system. One class is activated by depolarization; whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. This KIR2.3 protein is an integral membrane protein and member of the inward rectifier potassium channel family. It has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for its gene.
  • Synonyms

    KCNJ4;potassium inwardly-rectifying channel, subfamily J, member 4;inward rectifier potassium channel 4;HIR;hIRK2;HRK1;IRK3;Kir2.3;inward rectifier K+ channel Kir2.3;inward rectifier K(+) channel Kir2.3;hippocampal inward rectifier potassium cha

Recombinant Proteins

  • Human
  • Mesocricetus auratus
  • Rat
  • Mus musculus
  • HEK293
  • E.coli
  • Non
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
KCNJ4-5045HCL Recombinant Human KCNJ4 293 Cell Lysate HEK293 Human Non
KCNJ4-5046HCL Recombinant Human KCNJ4 293 Cell Lysate HEK293 Human Non
KCNJ4-2769H Recombinant Human KCNJ4 protein(231-310 aa), C-His-tagged E.coli Human His 231-310 aa
RFL11301HF Recombinant Full Length Human Inward Rectifier Potassium Channel 4(Kcnj4) Protein, His-Tagged E.coli Human His Full L. Full Length (1-445)
RFL12045MF Recombinant Full Length Mesocricetus Auratus Inward Rectifier Potassium Channel 4(Kcnj4) Protein, His-Tagged E.coli Mesocricetus auratus His Full L. Full Length (1-444)
RFL15642RF Recombinant Full Length Rat Inward Rectifier Potassium Channel 4(Kcnj4) Protein, His-Tagged E.coli Rat His Full L. Full Length (1-446)
RFL22613MF Recombinant Full Length Mouse Inward Rectifier Potassium Channel 4(Kcnj4) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-445)

    Involved Pathway

    KCNJ4 involved in several pathways and played different roles in them. We selected most pathways KCNJ4 participated on our site, such as Activation of G protein gated Potassium channels,Activation of GABAB receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cholinergic synapse CREB3L1,KCNQ2,GNA11,GNG10,CAMK4,GNG2,CHRM4,GNAQ,CAMK2G,KCNJ3
    Classical Kir channels KCNJ12,KCNJ14,KCNJ2,KCNJ2A
    GABA B receptor activation KCNJ5,KCNJ12,KCNJ2A,KCNJ15,KCNJ9,KCNJ10,GNGT2B,GNB3A,KCNJ6,GNGT2A
    Activation of GABAB receptors KCNJ3,KCNJ2,KCNJ2A,KCNJ6,ADCY8,GNGT2A,KCNJ10,KCNJ5,ADCY6,ADCY9
    G protein gated Potassium channels KCNJ2A,GNGT2A,GNGT2B,KCNJ15,GNB3A,KCNJ9,KCNJ2,KCNJ5,KCNJ12,KCNJ6
    Activation of G protein gated Potassium channels KCNJ15,KCNJ3,GNB3B,GNB3A,KCNJ2A,KCNJ12,KCNJ6,GNGT2B,KCNJ2,KCNJ9
    Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits KCNJ2A,KCNJ12,KCNJ10,KCNJ15,GNGT2A,GNGT2B
    GABA receptor activation KCNJ2,KCNJ15,ARHGEF9,GNGT2A,GABRR2A,KCNJ2A,GNGT2B,KCNJ12,GNB3A,KCNJ9

    Protein Function

    KCNJ4 has several biochemical functions, for example, PDZ domain binding,inward rectifier potassium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ4 itself. We selected most functions KCNJ4 had, and list some proteins which have the same functions with KCNJ4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding UBE2Q1,CDKN3,ISOC2,PSMA1,LRP1,ASIC1,UBE2IB,POT1A,SRGAP3,WASL
    PDZ domain binding FZD3,MAP2K2,ATP2B1A,KIDINS220,GRIK5,LNX1,ATP2B3A,SSTR2,BAIAP2,CADM1
    inward rectifier potassium channel activity KCNJ1A.6,KCNJ16,KCNJ1A.5,KCNH2,KCNJ1A.1,KCNK6,KCNJ1A.3,KCNJ2,KCNJ1A.4,KCNJ14

    Interacting Protein

    KCNJ4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ4.

    Dlg1;LIN7B;Cask;Lin7c

    Resources

    References

    • Zhu, XZ; Liang, J; et al. Calcium Intake and Ion Transporter Genetic Polymorphisms Interact in Human Colorectal Neoplasia Risk in a 2-Phase Study. JOURNAL OF NUTRITION 144:1734-1741(2014).
    • Li, Q; Chen, M; et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41:748-754(2014).

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