KCNJ4
-
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 4 -
Overview
Various potassium channels are involved with electrical signaling in the nervous system. One class is activated by depolarization; whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. This KIR2.3 protein is an integral membrane protein and member of the inward rectifier potassium channel family. It has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for its gene. -
Synonyms
KCNJ4;potassium inwardly-rectifying channel, subfamily J, member 4;inward rectifier potassium channel 4;HIR;hIRK2;HRK1;IRK3;Kir2.3;inward rectifier K+ channel Kir2.3;inward rectifier K(+) channel Kir2.3;hippocampal inward rectifier potassium cha
Recombinant Proteins
- Human
- Mesocricetus auratus
- Rat
- Mus musculus
- HEK293
- E.coli
- Non
- His
Involved Pathway
KCNJ4 involved in several pathways and played different roles in them. We selected most pathways KCNJ4 participated on our site, such as Activation of G protein gated Potassium channels,Activation of GABAB receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G protein gated Potassium channels | GNGT2B,KCNJ5,GNB3B,KCNJ6,KCNJ15,KCNJ9,GNB3A,GNGT2A,KCNJ2,KCNJ10 |
| Activation of GABAB receptors | KCNJ6,KCNJ15,ADCY1,KCNJ3,ADCY6,KCNJ12,GNB3B,GNB3A,KCNJ5,KCNJ9 |
| GABA receptor activation | KCNJ2A,KCNJ9,GNGT2A,KCNJ15,GNGT2B,GNB3A,KCNJ12,KCNJ2,GABRR2A,KCNJ10 |
| Cholinergic synapse | PLCB4,CHRM4,FYN,CHRNA6,PRKCG,GNG3,PIK3CG,PIK3R1,CHRNA7,KCNQ3 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | GNGT2A,KCNJ2A,KCNJ12,KCNJ10,GNGT2B,KCNJ15 |
| Activation of G protein gated Potassium channels | KCNJ5,GNB3A,KCNJ2,KCNJ15,KCNJ9,KCNJ2A,GNGT2A,GNGT2B,KCNJ6,KCNJ3 |
| GABA B receptor activation | GNGT2A,KCNJ12,GNB3A,KCNJ2A,KCNJ10,KCNJ5,KCNJ2,KCNJ6,GNGT2B,KCNJ15 |
| Classical Kir channels | KCNJ2,KCNJ2A,KCNJ12,KCNJ14 |
Protein Function
KCNJ4 has several biochemical functions, for example, PDZ domain binding,inward rectifier potassium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ4 itself. We selected most functions KCNJ4 had, and list some proteins which have the same functions with KCNJ4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | FZD3,DOCK4,ADAM17,PSEN1,SRR,ATP2B2,DLG3,MAP2K2,LNX1,SLC22A5 |
| protein binding | FCRL2,BMX,ARRB1,AFF4,ECE1,GTF2H3,SUDS3,FANCI,PXN,TXNL4A |
| inward rectifier potassium channel activity | KCNQ5,KCNJ1A.4,KCNJ18,KCNJ1A.5,KCNJ1A.1,KCNJ14,KCNJ1A.6,KCNJ2A,KCNJ2,KCNJ1 |
Interacting Protein
KCNJ4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ4.
Dlg1;LIN7B;Cask;Lin7c
Resources
Related Services
Related Products
References
- Zhu, XZ; Liang, J; et al. Calcium Intake and Ion Transporter Genetic Polymorphisms Interact in Human Colorectal Neoplasia Risk in a 2-Phase Study. JOURNAL OF NUTRITION 144:1734-1741(2014).
- Li, Q; Chen, M; et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41:748-754(2014).
