KCND2
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Official Full Name
potassium voltage-gated channel, Shal-related subfamily, member 2 -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. -
Synonyms
KCND2;potassium voltage-gated channel, Shal-related subfamily, member 2;potassium voltage-gated channel subfamily D member 2;KIAA1044;Kv4.2;RK5;voltage-sensitive potassium channel;voltage-gated potassium channel Kv4.2;voltage-gated potassium chann
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Mouse
- Oryctolagus cuniculus (Rabbit)
- Rat
- Mustela putorius furo (European domestic ferret) (Mustela furo)
- E.coli
- Mammalian Cells
- Yeast
- HEK293
- GST
- His
- His&Fc&Avi
Involved Pathway
KCND2 involved in several pathways and played different roles in them. We selected most pathways KCND2 participated on our site, such as Neuronal System,Potassium Channels,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCND2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Voltage gated Potassium channels | KCNA2B,KCNV2,KCNG4A,KCNS3,KCNC4,KCNH5,KCNH1A,KCNC2,KCNH1,KCNS2 |
| Serotonergic synapse | BRAF,PLCB1,HTR2A,PTGS1,SLC6A4,GNG8,CYP4X1,HTR1E,CYP2C70,GNAO1 |
| Neuronal System | KCNK13A,DLG1L,KCNS3,CPLX1,KCNC2,KCNC4,SLC1A7B,KCNQ2,CHRNA2,KCNJ11 |
| Potassium Channels | KCNH1B,KCNA6,KCNK18,KCNQ2,KCNC1B,KCNH2,KCNAB2B,KCNC1A,KCNA5,DDX1 |
Protein Function
KCND2 has several biochemical functions, for example, A-type (transient outward) potassium channel activity,NOT delayed rectifier potassium channel activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCND2 itself. We selected most functions KCND2 had, and list some proteins which have the same functions with KCND2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| A-type (transient outward) potassium channel activity | KCNIP2 |
| protein binding | RAB27A,CSDC2,TMEM199,SERTAD3,VPS72,BSCL2,MUL1,NAT10,TFDP1,CCND3 |
| NOT delayed rectifier potassium channel activity | KCNA4,KCND3 |
| metal ion binding | TRIM109,ATP1A3,ZNF324,KCND3,STEAP4,CRBN,FAM164C,ZNF454,TGFBR1,PPM1DA |
| voltage-gated potassium channel activity | CNGA2,KCNQ2,KCNK5,KCNH2A,KCNC3B,KCNH1A,KCNMA1,KCNH6A,KCNA4,KCNH8 |
Interacting Protein
KCND2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCND2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCND2.
KCNIP2;KCNIP2;KCNIP1
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