ITGB2
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Official Full Name
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -
Overview
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. -
Synonyms
95 subunit beta;Beta 2 (antigen CD18 (p95);CD 18;CD18;CD18 antigen;Cell surface adhesion glycoprotein LFA 1/CR3/P150, 959 beta subunit precursor);Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta;Cell surface adhesion glycoproteins LFA 1/CR3/p150, 95 subunit beta;Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit;Cell surface adhesion glycoproteins LFA-1/CR3/p150;Complement component 3 receptor 3 and 4 subunit;Complement receptor C3 beta subunit;Complement receptor C3 subunit beta;Integrin beta 2;Integrin beta chain beta 2;Integrin beta-2;Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit);ITB2_HUMAN;ITGB 2;ITGB2;LAD;LCAMB;Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C;Leukocyte Cell Adhesion Molecule CD18;LFA 1;LFA1;Lymphocyte function associated antigen 1;MAC 1;MAC1;Macrophage antigen 1 (mac1) beta subunit;MF17;MFI7;LFA-1;MAC-1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Mus musculus
- Bovine
- Sus scrofa (Pig)
- E.coli
- Wheat Germ
- Mammalian Cells
- Insect Cells
- HEK293
- Rat
- In Vitro Cell Free System
- His&T7
- Non
- His
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITGB2-181H | Recombinant Human ITGB2 protein, T7/His-tagged | E.coli | Human | His&T7 | 23-700 a.a. |
|
| ITGB2-26324TH | Recombinant Human ITGB2 | Wheat Germ | Human | Non | 769 amino acids |
|
| ITGB2-26325TH | Recombinant Human ITGB2 | Wheat Germ | Human | Non | 100 amino acids |
|
| ITGB2-6803C | Recombinant Chicken ITGB2 | Mammalian Cells | Chicken | His |
|
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| Itgb2-7145M | Recombinant Mouse Itgb2 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ala431~Met652 |
|
| Itgb2-7146R | Recombinant Rat Itgb2 protein, His & T7-tagged | E.coli | Rat | His&T7 | Val415~Gln678 |
|
| ITGB2-71H | Recombinant Human ITGB2 protein, His-tagged | Insect Cells | Human | His | 23-700 aa |
|
| ITGB2-5125HCL | Recombinant Human ITGB2 293 Cell Lysate | HEK293 | Human | Non |
|
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| DMABT-H24736 | Rat Anti-ITGB2 Monoclonal Antibody | Rat | Mouse | Non |
|
|
| ITGB2-1052H | Recombinant Human ITGB2 Protein (Gly124-Leu363), N-GST tagged | E.coli | Human | GST | Gly124-Leu363 |
|
| ITGB2-1067H | Recombinant Human ITGB2 Protein, His-tagged | E.coli | Human | His | Gln23-Val367 |
|
| ITGB2-1216H | Recombinant Human ITGB2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| ITGB2-1216H-B | Recombinant Human ITGB2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| ITGB2-1922H | Recombinant Human ITGB2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
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| ITGB2-248HFL | Active Recombinant Full Length Human ITGB2 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| ITGB2-2556H | Recombinant Human ITGB2 protein(451-520 aa), C-His-tagged | E.coli | Human | His | 451-520 aa |
|
| ITGB2-279HF | Recombinant Full Length Human ITGB2 Protein | In Vitro Cell Free System | Human | Full L. 769 amino acids |
|
|
| ITGB2-280HF | Recombinant Full Length Human ITGB2 Protein | In Vitro Cell Free System | Human | Full L. 100 amino acids |
|
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| Itgb2-3605M | Recombinant Mouse Itgb2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
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| ITGB2-4326H | Recombinant Human ITGB2 Protein (Met1-Asn700), C-His tagged | Mammalian Cells | Human | His | Met1-Asn700 |
|
| ITGB2-4978H | Recombinant Human ITGB2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| ITGB2-5780HF | Recombinant Full Length Human ITGB2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 769 amino acids |
|
| RFL179HF | Recombinant Full Length Human Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (23-769) |
|
| RFL20219MF | Recombinant Full Length Mouse Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length of Mature Protein (24-771) |
|
| RFL798BF | Recombinant Full Length Bovine Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli | Bovine | His | Full L. Full Length of Mature Protein (23-769) |
|
| RFL9256SF | Recombinant Full Length Pig Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli | Sus scrofa (Pig) | His | Full L. Full Length of Mature Protein (23-769) |
|
Involved Pathway
ITGB2 involved in several pathways and played different roles in them. We selected most pathways ITGB2 participated on our site, such as Rap signaling pathway,Phagosome,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral myocarditis | HLA-B,HLA-DQA2,RAC1,CASP8,HLA-DRB5,LAMA2,Casp3,HLA-G,HLA-DMA,CD40LG |
| Natural killer cell mediated cytotoxicity | MAPK1,KLRC1,MAP2K2,FAS,KIR2DL4,RAET1L,IFNA17,ICAM1,PTPN6,KLRC2 |
| Staphylococcus aureus infection | SELP,GM5077,FCGR3B,ITGB2L,H2-AA,FPR1,HLA-DRB1,CFH,HLA-DPB1,C1S |
| Rap signaling pathway | KITLG,FGFR4,DOCK4,PDGFRA,PIK3R1,LPAR2,MET,MAPK12,FGF4,GRIN2B |
| Tuberculosis | PPP3CA,PIK3C3,IL12B,IFNA4,IFNA1,RAB5C,CALM3,TLR9,SYK,HLA-DRB4 |
| Legionellosis | TLR4,CR1,IL6,VCP,NFKBIA,SAR1A,NAIP1,IL1B,NLRC4,RELA |
| Amoebiasis | SERPINB1C,SERPINB6,HSPB1,ACTN2,LAMA3,PIK3CD,PIK3R5,COL5A2,LAMB2,PRKACA |
| Rheumatoid arthritis | ATP6V1G2,MMP1,CXCL5,CCL3L1,IFNG,TEK,IL-8,CD86,TNFSF13,TNFSF13B |
| HTLV-I infection | TERT,IKBKG,DVL1,VDAC3,TCF3,MAP3K3,KRAS,POLE4,RANBP3,SLC25A31 |
Protein Function
ITGB2 has several biochemical functions, for example, ICAM-3 receptor activity,cell adhesion molecule binding,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB2 itself. We selected most functions ITGB2 had, and list some proteins which have the same functions with ITGB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GP1BA,Arid4b,ZNF434,STRN,COP1,LRRC26,DLL1,AP3S1,ADAMTS5,LENG1 |
| glycoprotein binding | SERPINA1A,ACE2,RASA1,HSPA5,CNTN2,Serpina1b,AZGP1,LMAN2,THBS1,LGALS1 |
| ICAM-3 receptor activity | CLEC4M,ITGAL |
| metal ion binding | ZFP541,SMYD4,ANTXR2,ZFP11,ZNF174,ZC3H13,ZSCAN20,TIMP2,CMTM2A,PCGF5B |
| protein kinase binding | DUSP3,CCNT2B,GYS1,LLGL1,SREBF1,SYN1,RAD9A,ACVRL1,TENC1,EEF1A1 |
| cell adhesion molecule binding | CADM4,PTPRD,ITGB1,CADM1A,NLGN1,ITGAL,ADAM8,PVRL1B,NRXN2,JUP |
Interacting Protein
ITGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB2.
RANBP9;TLN2;NOTCH2NL;RDX;COPS3;ABL1
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References
- Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
- Madkaikar, M; Italia, K; et al. Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. BLOOD CELLS MOLECULES AND DISEASES 54:217-223(2015).
