IL31
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Official Full Name
interleukin 31 -
Overview
IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. -
Synonyms
IL31;interleukin 31;interleukin-31;IL 31;IL-31
Recombinant Proteins
- Human
- Dog
- Mouse
- Rat
- Cynomolgus
- HEK293
- E.coli
- Mammalian Cell
- Human Cells
- Insect Cell
- Mammalian cells
- Insect Cells
- StrepII
- Non
- His
- His&GST
- His&Myc
- His&Fc&Avi
- His&Avi
Involved Pathway
IL31 involved in several pathways and played different roles in them. We selected most pathways IL31 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL31 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IL31 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL31 itself. We selected most functions IL31 had, and list some proteins which have the same functions with IL31. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | SPAW,IFNL3,FLT3LG,NODAL,SCG2,IL12BA,CMTM5,GDF6B,HMGB1,TSLP |
Interacting Protein
IL31 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL31 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL31.
Resources
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References
- Yu, JI; Park, YR; et al. Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis. JOURNAL OF GENETICS 93:813-817(2014).
- Maier, E; Werner, D; et al. Human Th2 but Not Th9 Cells Release IL-31 in a STAT6/NF-kappa B-Dependent Way. JOURNAL OF IMMUNOLOGY 193:645-654(2014).
