IL12RB1
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Official Full Name
interleukin 12 receptor, beta 1 -
Overview
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor;superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12;receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The;coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and;reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the;immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript;variants of this gene encoding distinct isoforms have been reported. -
Synonyms
IL12RB1;interleukin 12 receptor, beta 1;IL12RB;interleukin-12 receptor subunit beta-1;CD212;I12R1_HUMAN;IL-12 receptor beta component;IL-12 receptor subunit beta-1;IL-12R subunit beta-1;IL-12R-beta-1;IL-12RB1;IL12 receptor beta component;Interleukin 12 receptor beta 1 chain;Interleukin 12 receptor subunit beta 1;MGC34454;interleukin-12 receptor beta-1 chain;IL-12R-BETA1
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- HEK293
- CHO cells
- Mammalian cells
- E.coli
- Insect Cell
- Mammalian Cell
- Human Cell
- HEK293T
- E.coli expression system
- His
- His&Avi
- Fc&Avi
- Non
- His&GST
- Fc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
IL12RB1 involved in several pathways and played different roles in them. We selected most pathways IL12RB1 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12RB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF14,IL17RA,ACVR1BA,GM13306,PLEKHO2,GDF5,NT5C3,CXCR3.1,IL18RAP,CCL21B |
| Inflammatory bowel disease (IBD) | RORC,RELA,IL22,IL18RAP,IL21R,IFNGR2,NFKB1,IL23R,IL5,IL1B |
| Jak-STAT signaling pathway | CSF3R,EPOR,GRB2A,IFNA1,JAK2B,CRFB16,TYK2,IL20RA,PIAS4B,IL2RB |
Protein Function
IL12RB1 has several biochemical functions, for example, cytokine receptor activity,contributes_to interleukin-12 receptor activity,contributes_to interleukin-12 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12RB1 itself. We selected most functions IL12RB1 had, and list some proteins which have the same functions with IL12RB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to interleukin-12 receptor binding | IL12B,IL23R |
| contributes_to interleukin-23 binding | IL23R |
| contributes_to interleukin-23 receptor activity | IL23R |
| cytokine receptor activity | IL13RA1,CD74,IL20RA,IL21R.2,CRFB4,IL13RA2,FLT3,LIFRB,IL12B,GHRA |
Interacting Protein
IL12RB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12RB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12RB1.
IL12A;IL12B;SNRPD3;il23a_il-12b_human
IL12RB1 Related Signal Pathway
Resources
Research Area
Negative Regulators of the Jak/STAT PathwayReceptors in the Jak/STAT Pathway
T Cell Cytokine Signaling
Macrophage Markers
Th1 Cells
IL-12 Family Receptors
Related Services
Related Products
References
- Famulski, KS; Reeve, J; et al. Kidney Transplants With Progressing Chronic Diseases Express High Levels of Acute Kidney Injury Transcripts. AMERICAN JOURNAL OF TRANSPLANTATION 13:634-644(2013).
- Tang, SW; Yang, TC; et al. Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. CARCINOGENESIS 32:138-145(2011).
