IGFBP7

  • Official Full Name

    insulin-like growth factor binding protein 7
  • Overview

    This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
  • Synonyms

    IGFBP7;insulin-like growth factor binding protein 7;AGM;PSF;TAF;FSTL2;IBP-7;MAC25;IGFBP-7;RAMSVPS;IGFBP-7v;IGFBPRP1;insulin-like growth factor-binding protein 7;IGFBP-rP1;angiomodulin;IGF-binding protein 7;PGI2-stimulating factor;tumor-derived adhesion factor;prostacyclin-stimulating factor

Recombinant Proteins

  • Mouse
  • Zebrafish
  • Human
  • Rat
  • S.frugiperda
  • Mammalian Cells
  • E.coli
  • Human
  • HEK293
  • Human Cells
  • His
  • T7
  • Non
  • Fc
  • DDK
  • Myc
  • Avi
  • SUMO
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
Igfbp7-5645M Active Recombinant Mouse Insulin-Like Growth Factor Binding Protein 7, His-tagged S.frugiperda Mouse His 28-281 a.a.
IGFBP7-12177Z Recombinant Zebrafish IGFBP7 Mammalian Cells Zebrafish His
IGFBP7-1630H Recombinant Human IGFBP7, His-tagged Mammalian Cells Human His 30-282;1-16 a.a.
Igfbp7-1786M Recombinant Mouse Igfbp7 protein, His & T7-tagged E.coli Mouse His&T7 Lys88~Leu281
Igfbp7-1787R Recombinant Rat Igfbp7 protein, His-tagged E.coli Rat His Lys88~Leu281
IGFBP7-208H Recombinant Human IGFBP7 protein E.coli Human Non 256
IGFBP7-2483H Recombinant human IGFBP7, His-tagged E.coli Human His
IGFBP7-5054H Recombinant Human Insulin-Like Growth Factor Binding Protein 7 Human Human Non
IGFBP7-5165H Recombinant Human IGFBP7 protein, hFc-tagged HEK293 Human Fc Ser27-Leu282
IGFBP7-529H Recombinant Human IGFBP7 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
IGFBP7-55H Recombinant Human IGFBP7 protein E.coli Human Non
IGFBP7-6957H Active Recombinant Human IGFBP7 protein, His-tagged HEK293 Human His Asp30-Leu282
Igfbp7-971M Recombinant Mouse Igfbp7 Protein, Fc-tagged HEK293 Mouse Fc 1-281 a.a.
IGFBP7-1694HCL Recombinant Human IGFBP7 cell lysate Human Cells Human Non
IGFBP7-1604H Active Recombinant Human IGFBP7 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His 30-282 a.a.
IGFBP7-1605H Active Recombinant Human IGFBP7 protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi&Fc 30-282 a.a.
IGFBP7-1606H Active Recombinant Human IGFBP7 protein, Fc-tagged HEK293 Human Fc 30-282 a.a.
IGFBP7-160H Recombinant Human IGFBP7 Protein (Ser27-Leu282), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 Human His&SUMO Ser27-Leu282
IGFBP7-1656H Recombinant Human IGFBP7 Protein, His&GST-tagged E.coli Human GST&His Asp30-Leu282
IGFBP7-2280H Recombinant Human IGFBP7 Protein, His-tagged E.coli Human His Ser24-Leu50+Gly130-Leu282
IGFBP7-2281H Recombinant Human IGFBP7 protein, His-tagged HEK293 Human His Ser27-Leu282
IGFBP7-2949H Recombinant Human IGFBP7 Protein (Gly130-Ala280), N-His tagged E.coli Human His Gly130-Ala280
IGFBP7-303H Recombinant Human IGFBP7 Protein, His-tagged HEK293 Human His 282
IGFBP7-3141H Recombinant Human IGFBP7 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IGFBP7-3141H-B Recombinant Human IGFBP7 Protein Pre-coupled Magnetic Beads HEK293 Human
Igfbp7-3490M Recombinant Mouse Igfbp7 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
IGFBP7-533H Recombinant Human IGFBP7 protein, His-tagged E.coli Human His 27-282a.a.
Igfbp7-533M Recombinant Mouse Igfbp7 protein, His-tagged HEK293 Mouse His Ser26-Leu281
igfbp7-5456Z Recombinant Zebrafish igfbp7 Protein (Gln16-Leu257), N-His tagged E.coli Zebrafish His Gln16-Leu257
IGFBP7-6050H Recombinant Human IGFBP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IGFBP7-6958H Recombinant Human IGFBP7 protein, His-tagged HEK293 Human His Ser27-Leu282

    Involved Pathway

    IGFBP7 involved in several pathways and played different roles in them. We selected most pathways IGFBP7 participated on our site, such as Cellular Senescence,Cellular responses to stress,Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular Senescence CDKN2A,MINK1,CDKN2D,RING1,BMI1A,PHC2,RNF2,HMGA1-RS1,HIRA,EHMT2
    Senescence and Autophagy SLC39A3,UVRAG,IL24,MAP1LC3C,ATG7,COL10A1,IFI16,ING2,ING1,GABARAPL2
    Cellular responses to stress HMGA1-RS1,ATG7,TXN2,SUZ12A,TERF2IP,HIST4H4,SCMH1,HIST3H2BB,EPAS1B,BMI1B

    Protein Function

    IGFBP7 has several biochemical functions, for example, insulin-like growth factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP7 itself. We selected most functions IGFBP7 had, and list some proteins which have the same functions with IGFBP7. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PTK7,DNAJC28,SNTB1,TNFAIP8L1,PRC1,TAG-260,RIPPLY3,ZBTB44,NKX3,TRAF1
    insulin-like growth factor binding WISP2,IGFBP1A,CTGFB,IGFBP5A,HTRA1A,CTGFA,WISP1B,HTRA3,HTRA1B,IGFBP5B

    Interacting Protein

    IGFBP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP7.

    ST14;asnB;q81l39_bacan;dacA;glnK;clcA;hldE;RBBP8;q9r8c5_yerpe

    Resources

    References

    • Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
    • Chugh, S; Ouzounian, M; et al. Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PROTEOMICS 13:2324-2334(2013).

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