IGFBP7
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Official Full Name
insulin-like growth factor binding protein 7 -
Overview
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011] -
Synonyms
IGFBP7;insulin-like growth factor binding protein 7;AGM;PSF;TAF;FSTL2;IBP-7;MAC25;IGFBP-7;RAMSVPS;IGFBP-7v;IGFBPRP1;insulin-like growth factor-binding protein 7;IGFBP-rP1;angiomodulin;IGF-binding protein 7;PGI2-stimulating factor;tumor-derived adhesion factor;prostacyclin-stimulating factor
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rat
- S.frugiperda
- Mammalian Cells
- E.coli
- Human
- HEK293
- Human Cells
- His
- His&T7
- Non
- Fc
- Myc&DDK
- His&Avi
- Fc&Avi
- N-His-SUMO
- His&GST
- His&Fc&Avi
Involved Pathway
IGFBP7 involved in several pathways and played different roles in them. We selected most pathways IGFBP7 participated on our site, such as Cellular Senescence,Cellular responses to stress,Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular Senescence | BMI1A,TXN,RBB4L,Txn1,CBX8A,UBN1,RING1,LMNB1,EP400,TERF1 |
| Senescence and Autophagy | ING1,ING2,ATG7,SLC39A3,SLC39A2,FKBP8,SLC39A1,LC3,IFI16,COL10A1 |
| Cellular responses to stress | KDM6B,CHMP4C,HIF1AN,ATG101,HIST4H4,CDKN2B,DPF1,HSPH1,DNAJC2,CBX8B |
Protein Function
IGFBP7 has several biochemical functions, for example, insulin-like growth factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP7 itself. We selected most functions IGFBP7 had, and list some proteins which have the same functions with IGFBP7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DTD2,ACD,FMO4,MRE11A,MUC7,FBXO44,EZR,PSMC2,PTPN23,OSTA |
| insulin-like growth factor binding | DEFB126,KAZALD2,IGFBP2A,KAZALD1,CTGF,IGF2R,IGF1R,IGFBP5A,HTRA4,CYR61L1 |
Interacting Protein
IGFBP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP7.
ST14;asnB;q81l39_bacan;dacA;glnK;clcA;hldE;RBBP8;q9r8c5_yerpe
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References
- Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
- Chugh, S; Ouzounian, M; et al. Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PROTEOMICS 13:2324-2334(2013).
