HSD17B3
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 3 -
Overview
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone.It preferentially uses NADP as cofactor.Deficiency can result in male pseudohermaphroditism with gynecomastia. -
Synonyms
HSD17B3;hydroxysteroid (17-beta) dehydrogenase 3;testosterone 17-beta-dehydrogenase 3;SDR12C2;short chain dehydrogenase/reductase family 12C;member 2;17 @beta HSD III;17 beta HSD 3;17-@beta hydroxysteroid dehydrogenase III;17-beta-hydroxysteroid dehydrogenase type 3;EC 1.1.1.64;EDH17B3;Estradiol 17 beta dehydrogenase;Estradiol 17 beta dehydrogenase 3;Hydroxysteroid (17 beta) dehydrogenase 3;OTTHUMP00000021718;Testicular 17 @beta hydroxysteroid dehydrogenaseIII;Testicular 17 beta hydroxysteroid dehydrogenase;Testosterone 17 beta dehydrogenase 3;17-beta-HSD3;17-beta-HSD 3;testicular 17-beta-hydroxysteroid dehydrogenase;short chain dehydrogenase/reductase family 12C, member 2
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HSD17B3 involved in several pathways and played different roles in them. We selected most pathways HSD17B3 participated on our site, such as Steroid hormone biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CYP11C1,POLG2,CMPK2,MBOAT2,LSM1,POLD2,COX17,C1GALT1B,ASAH2,PYCR2 |
| Steroid hormone biosynthesis | CYP2C50,H2-KE6,HSD17B12,UGT1A6,HSD17B12A,AKR1C3,AKR1D1,CYP2C45,AKR1C2,CYP3A7-CYP3AP1 |
Protein Function
HSD17B3 has several biochemical functions, for example, testosterone 17-beta-dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B3 itself. We selected most functions HSD17B3 had, and list some proteins which have the same functions with HSD17B3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| testosterone 17-beta-dehydrogenase (NADP+) activity | AKR1C6,HSD17B14,AKR1C3 |
Interacting Protein
HSD17B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B3.
BUB1;ERBB2;CDH1;BRAF;MCC;CTNNA1;MLH1;SMAD2;DLC1;MLH3
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References
- Guo, JJ; Li, XW; et al. The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis. TOXICOLOGY 306:9-15(2013).
