HS3ST1
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Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -
Overview
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. -
Synonyms
HS3ST1;heparan sulfate (glucosamine) 3-O-sulfotransferase 1;heparan sulfate glucosamine 3-O-sulfotransferase 1;3OST1;3-OST-1;3OST;EC 2.8.2.23;h3 OST 1;h3-OST-1;Heparan sulfate (glucosamine) 3 O sulfotransferase 1;Heparan sulfate 3 O sulfotransferase 1;Heparan sulfate D glucosaminyl 3 O sulfotransferase 1;Heparin glucosamine 3 O sulfotransferase;HS3ST 1;heparan sulfate 3-O-sulfotransferase 1;heparin-glucosamine 3-O-sulfotransferase;heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- CHO
- Mammalian Cell
- E.coli
- Insect Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HS3ST1 involved in several pathways and played different roles in them. We selected most pathways HS3ST1 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, which may be useful for your reference. Also, other proteins which involved in the same pathway with HS3ST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | B3GALT6,MAPK1IP1L,HS2ST1A,EXTL3,HS2ST1,HS6ST1A,EXT1B,HS6ST2,HS3ST5,NDST2 |
Protein Function
HS3ST1 has several biochemical functions, for example, [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity,sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HS3ST1 itself. We selected most functions HS3ST1 had, and list some proteins which have the same functions with HS3ST1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | HS3ST6,HS3ST5,HS3ST3B1,HS3ST4 |
| sulfotransferase activity | SULT5A1,CHST2,SULT1A2,HS3ST1L2,SULT2ST2,SULT1ST5,SULT1ST2,UST,SULT1B1,SULT2ST1 |
Interacting Protein
HS3ST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HS3ST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HS3ST1.
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References
- Liu, JA; Shriver, Z; et al. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues. JOURNAL OF BIOLOGICAL CHEMISTRY 274:38155-38162(1999).
